American Society of Hematology 2019 guidelines for immune thrombocytopenia

C Neunert, DR Terrell, DM Arnold, G Buchanan… - Blood …, 2019 - ashpublications.org
Background: Despite an increase in the number of therapies available to treat patients with
immune thrombocytopenia (ITP), there are minimal data from randomized trials to assist …

Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP)

A Zufferey, R Kapur, JW Semple - Journal of clinical medicine, 2017 - mdpi.com
Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low
platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated …

Clinical updates in adult immune thrombocytopenia

MP Lambert, TB Gernsheimer - Blood, The Journal of the …, 2017 - ashpublications.org
Immune thrombocytopenia (ITP) occurs in 2 to 4/100 000 adults and results in variable
bleeding symptoms and thrombocytopenia. In the last decade, changes in our …

Platelets and the immune continuum

JW Semple, JE Italiano, J Freedman - Nature Reviews Immunology, 2011 - nature.com
Platelets are anucleate cells that are crucial mediators of haemostasis. Most immunologists
probably don't think about platelets every day, and may even consider these cells to …

Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia

J Li, DE Van Der Wal, G Zhu, M Xu, I Yougbare… - Nature …, 2015 - nature.com
Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by
autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests …

Emerging concepts in immune thrombocytopenia

M Swinkels, M Rijkers, J Voorberg… - Frontiers in …, 2018 - frontiersin.org
Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts
which presents with an increased bleeding risk. Several genetic risk factors (eg …

Epidemiology of incident immune thrombocytopenia: a nationwide population-based study in France

G Moulis, A Palmaro, JL Montastruc… - Blood, The Journal …, 2014 - ashpublications.org
The epidemiology of immune thrombocytopenia (ITP) is not well known. The purpose of this
study was to assess ITP incidence at a nationwide level (France) with recent data (mid-2009 …

Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment

O Miltiadous, M Hou, JB Bussel - Blood, The Journal of the …, 2020 - ashpublications.org
Immune thrombocytopenia (ITP) is the most common acquired thrombocytopenia after
chemotherapy-induced thrombocytopenia. Existing guidelines describe the management …

Splenectomy for immune thrombocytopenia: down but not out

S Chaturvedi, DM Arnold… - Blood, The Journal of the …, 2018 - ashpublications.org
Splenectomy is an effective therapy for steroid-refractory or dependent immune
thrombocytopenia (ITP). With the advent of medical alternatives such as rituximab and …

Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification

P Strati, TD Shanafelt - Blood, The Journal of the American …, 2015 - ashpublications.org
Monoclonal B lymphocytosis (MBL) is defined as the presence of a clonal B-cell population
in the peripheral blood with fewer than 5× 109/L B-cells and no other signs of a …