Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …

Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Inflammation triggers pulmonary vascular remodelling. Ferroptosis, a nonapoptotic form of
cell death that is triggered by iron-dependent lipid peroxidation and contributes to the …

With its complicated pathobiology and pathophysiology, heart failure (HF) remains an
increasingly prevalent epidemic that threatens global human health. Ferroptosis is a form of …

Heart disease is the leading cause of death worldwide. Cardiomyopathy is a disease
characterized by the heart muscle damage, resulting heart in a structurally and functionally …

Cardiotoxicity has emerged as a major side effect of doxorubicin (DOX) treatment, affecting
nearly 30% of patients within 5 years after chemotherapy. Heart failure is the first non-cancer …

Abstract Aloe-emodin (AE), a novel ferroptosis inhibitor, alleviates the doxorubicin (DOX)-
induced cardiotoxicity in H9c2 rat cardiomyocytes. The inhibition of ferroptosis and the …

Sepsis is a common critical illness in the Intensive care unit (ICU) and its management and
treatment has always been a major challenge in critical care medicine. The dysregulated …

Doxorubicin (DOX) is a most common anthracycline chemotherapeutic agent; however, its
clinical efficacy is limited due to its severe and irreversible cardiotoxicity. Ferroptosis …

Iron is indispensable in numerous biologic processes, but abnormal iron regulation and
accumulation is related to pathological processes in cardiovascular diseases. However, the …