Splicing: is there an alternative contribution to Parkinson's disease?
Alternative splicing is a crucial mechanism of gene expression regulation that enormously
increases the coding potential of our genome and represents an intermediate step between …
increases the coding potential of our genome and represents an intermediate step between …
The synaptic function of parkin
J Sassone, GM Serratto, F Valtorta, V Silani… - Brain, 2017 - academic.oup.com
Loss of function mutations in the gene PARK2, which encodes the protein parkin, cause
autosomal recessive juvenile parkinsonism, a neurodegenerative disease characterized by …
autosomal recessive juvenile parkinsonism, a neurodegenerative disease characterized by …
Regulation of Parkin expression as the key balance between neural survival and cancer cell death
FE Murillo-González, R García-Aguilar, L Vega… - Biochemical …, 2021 - Elsevier
Parkin is a cytosolic E3 ubiquitin ligase that plays an important role in neuroprotection by
targeting several proteins to be degraded by the 26S proteasome. Its dysfunction has been …
targeting several proteins to be degraded by the 26S proteasome. Its dysfunction has been …
Does the expression and epigenetics of genes involved in monogenic forms of Parkinson's disease influence sporadic forms?
A Lanore, S Lesage, LL Mariani, PJ Menon… - Genes, 2022 - mdpi.com
Parkinson's disease (PD) is a disorder characterized by a triad of motor symptoms (akinesia,
rigidity, resting tremor) related to loss of dopaminergic neurons mainly in the Substantia …
rigidity, resting tremor) related to loss of dopaminergic neurons mainly in the Substantia …
Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain
Parkinson protein 2, E3 ubiquitin protein ligase (PARK2) gene mutations are the most
frequent causes of autosomal recessive early onset Parkinson's disease and juvenile …
frequent causes of autosomal recessive early onset Parkinson's disease and juvenile …
The PINK1—Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells
Mutations in the PINK1 and PRKN genes are the most common cause of early-onset familial
Parkinson disease. These genes code for the PINK1 and Parkin proteins, respectively …
Parkinson disease. These genes code for the PINK1 and Parkin proteins, respectively …
Increasing the coding potential of genomes through alternative splicing: the case of PARK2 gene
V La Cognata, R Iemmolo, V D'Agata… - Current …, 2014 - ingentaconnect.com
The completion of the Human Genome Project aroused renewed interest in alternative
splicing, an efficient and widespread mechanism that generates multiple protein isoforms …
splicing, an efficient and widespread mechanism that generates multiple protein isoforms …
Proteomic studies associated with Parkinson's disease
Introduction: Parkinson's disease (PD) is an insidious disorder affecting more than 1–2% of
the population over the age of 65. Understanding the etiology of PD may create …
the population over the age of 65. Understanding the etiology of PD may create …
Linking a compound-heterozygous Parkin mutant (Q311R and A371T) to Parkinson's disease by using proteomic and molecular approaches
Parkin is an E3-protein ubiquitin ligase, which plays an important role as a scavenger in cell
metabolism. Since the discovery of the link between Parkin and Parkinson's disease, Parkin …
metabolism. Since the discovery of the link between Parkin and Parkinson's disease, Parkin …
The PARK2 Mutation Associated with Parkinson's Disease Enhances the Vulnerability of Peripheral Blood Lymphocytes to Paraquat
F Ming, J Tan, L Qin, H Zhang, J Tang… - BioMed Research …, 2020 - Wiley Online Library
Parkinson's disease (PD) is the second most common neurodegenerative disease in middle‐
aged and elderly people. However, the etiology and pathogenesis of PD are still unclear …
aged and elderly people. However, the etiology and pathogenesis of PD are still unclear …