The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …

Protein kinase C (PKC) isozymes belong to a family of Ser/Thr kinases whose activity is
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …

Several mechanisms could account for the greater than expected degree of insulin
resistance in these individuals. First, because the insulin receptor precursor can form …

Zinc is an essential trace element crucial for the function of more than 300 enzymes and it is
important for cellular processes like cell division and apoptosis. Hence, the concentration of …

▪ Abstract The insulin resistance syndrome refers to a constellation of findings, including
glucose intolerance, obesity, dyslipidemia, and hypertension, that promote the development …

Insulin-stimulated glucose uptake in adipose tissue and striated muscle is critical for
reducing post-prandial blood glucose concentrations and the dysregulation of this process is …

New molecules discovered during the past ten years have created a rational framework to
understand signalling transduction by a broad range of growth factors and cytokines …

Initial attempts to unravel the molecular mechanism of insulin resistance have strongly
suggested that a defect responsible for insulin resistance in the majority of patients lies at …

Since the discovery of insulin roughly 80 yr ago, much has been learned about how target
cells receive, interpret, and respond to this peptide hormone. For example, we now know …

Insulin, the major hormonal regulator of glucose transport in humans, has served as a
prototypic molecule for understanding cell signaling pathways since its discovery in 1922. It …