Child health, developmental plasticity, and epigenetic programming

Z Hochberg, R Feil, M Constancia, M Fraga… - Endocrine …, 2011 - academic.oup.com
Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

The role of epigenetics in aging and age-related diseases

V Calvanese, E Lara, A Kahn, MF Fraga - Ageing research reviews, 2009 - Elsevier
The role of epigenetics in aging and age-related diseases is a key issue in molecular
physiology and medicine because certain epigenetic factors are thought to mediate, at least …

A practical guide to linking brain-wide gene expression and neuroimaging data

A Arnatkevic̆iūtė, BD Fulcher, A Fornito - Neuroimage, 2019 - Elsevier
The recent availability of comprehensive, brain-wide gene expression atlases such as the
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …

Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific …

L Gordon, JE Joo, JE Powell, M Ollikainen… - Genome …, 2012 - genome.cshlp.org
Comparison between groups of monozygotic (MZ) and dizygotic (DZ) twins enables an
estimation of the relative contribution of genetic and shared and nonshared environmental …

Multi-omics research strategies in ischemic stroke: A multidimensional perspective

W Li, C Shao, H Zhou, H Du, H Chen, H Wan… - Ageing Research …, 2022 - Elsevier
Ischemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high
rate of death and long-term impairment. Despite years of studies, there are still no stroke …

[HTML][HTML] Where the genome meets the connectome: understanding how genes shape human brain connectivity

A Arnatkeviciute, BD Fulcher, MA Bellgrove, A Fornito - Neuroimage, 2021 - Elsevier
The integration of modern neuroimaging methods with genetically informative designs and
data can shed light on the molecular mechanisms underlying the structural and functional …

[HTML][HTML] Imaging transcriptomics of brain disorders

A Arnatkeviciute, BD Fulcher, MA Bellgrove… - … Psychiatry Global Open …, 2022 - Elsevier
Noninvasive neuroimaging is a powerful tool for quantifying diverse aspects of brain
structure and function in vivo, and it has been used extensively to map the neural changes …

Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress–diathesis model of depression

L Booij, D Wang, ML Lévesque… - … Transactions of the …, 2013 - royalsocietypublishing.org
The functioning of the hypothalamic–pituitary–adrenal (HPA) axis and serotonergic (5-HT)
system are known to be intertwined with mood. Alterations in these systems are often …

Genetic and epigenetic regulation of aging

MF Fraga - Current opinion in immunology, 2009 - Elsevier
Many age-associated conditions, such as the decrease in regenerative capacity of tissues,
appear to be determined by a decline in the function of specific somatic stem cells. Although …

The Brisbane Systems Genetics Study: genetical genomics meets complex trait genetics

JE Powell, AK Henders, AF McRae, A Caracella… - PloS one, 2012 - journals.plos.org
There is growing evidence that genetic risk factors for common disease are caused by
hereditary changes of gene regulation acting in complex pathways. Clearly understanding …