Recent advances on biologically active coumarin-based hybrid compounds

M Yildirim, S Poyraz, M Ersatir - Medicinal Chemistry Research, 2023 - Springer
Coumarin hybrids have been designed and synthesized as an important new strategy in the
field of medicinal chemistry. Coumarin core has been shown to form various compounds to …

Recent insights about pyrrolidine core skeletons in pharmacology

S Poyraz, HA Döndaş, NY Döndaş… - Frontiers in …, 2023 - frontiersin.org
To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin
are utilized, and notably, the emergence of various side effects of existing drugs used for …

Indole/isatin‐containing hybrids as potential antibacterial agents

F Song, Z Li, Y Bian, X Huo, J Fang… - Archiv der …, 2020 - Wiley Online Library
The emergence and worldwide spread of drug‐resistant bacteria have already posed a
serious threat to human life, creating the urgent need to develop potent and novel …

Design, synthesis, biological evaluation and docking analysis of pyrrolidine-benzenesulfonamides as carbonic anhydrase or acetylcholinesterase inhibitors and …

S Poyraz, HA Döndaş, C Yamali… - Journal of …, 2024 - Taylor & Francis
The synthesis and biological assessment of novel multi-functionalized pyrrolidine-containing
benzenesulfonamides were reported along with their antimicrobial, antifungal, CAs …

N-Benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an imidazole moiety: Synthesis, characterization, crystal structure, in vitro ChEs inhibition, and …

S Poyraz, HA Döndaş, JM Sansano, S Belveren… - Journal of Molecular …, 2023 - Elsevier
A series of novel N-benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an
imidazole moiety has been prepared and their various biological activities are evaluated …

Ultrasonic cavitation facilitates rapid synthesis of trisubstituted pyrazole scaffolds through Michael addition/domino cyclization

D Kannan, S Naveen, G Jagadeesan… - …, 2019 - Wiley Online Library
A series of aryl/indolyl substituted 4, 5‐dihydro‐1H‐pyrazole derivatives were synthesized
via a domino method based on Michael addition mediated cyclization of appropriate …

From bioactive pyrrolidino [3, 4-c] pyrrolidines to more bioactive pyrrolidino [3, 4-b] pyrrolidines via ring-opening/ring-closing promoted by sodium methoxide

S Belveren, O Larranaga, S Poyraz, HA Dondas… - …, 2019 - thieme-connect.com
The process involving a rearrangement of pyrrolidino [3, 4-c] pyrrolidine to another
pyrrolidino [3, 4-b] pyrrolidine using sodium methoxide as base is fully studied. The effects of …

Acid Ionization Constants of Some N-Benzoylthiourea-Pyrrolidine Derivatives Bearing an Indole Ring by Potentiometric Titration in DMSO–Water

S Poyraz, S Belveren, HA Döndaş, H Sari - Russian Journal of General …, 2024 - Springer
The acid ionization constants (p K a) of N-benzoylthiourea pyrrolidine derivatives bearing
indole were calculated using the HYPERQUAD program with data from potentiometric …

Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo [3, 4-c] pyrrole-1, 3 …

S Belveren, S Poyraz, CM Pask, M Ülger… - Inorganica Chimica …, 2019 - Elsevier
Platinum complexes, derived from two families of bidentate funcionalized aroylaminocarbo-
N-thyoyl prolinates, are prepared using mild conditions from prolinates, which are available …

Synthesis, structure and bioactivity of a mononuclear octahedral [prolinate2-Na (MeOH) 4]− H+ complex

S Belveren, S Poyraz, M Ülger, CM Pask… - Inorganica Chimica …, 2020 - Elsevier
The synthesis of a mononuclear octahedral [Prolinate 2-Na (MeOH) 4]− H+ complex is
achieved from a [3+ 2] cycloadduct with excess of NaOMe in methanol. The slow …