[HTML][HTML] Nanovaccines: a game changing approach in the fight against infectious diseases

MAH Abusalah, H Chopra, A Sharma… - Biomedicine & …, 2023 - Elsevier
The field of nanotechnology has revolutionised global attempts to prevent, treat, and
eradicate infectious diseases in the foreseen future. Nanovaccines have proven to be a …

Regulatory T cells (Tregs) and COVID-19: unveiling the mechanisms, and therapeutic potentialities with a special focus on long COVID

M Dhawan, AA Rabaan, S Alwarthan, M Alhajri… - Vaccines, 2023 - mdpi.com
The COVID-19 pandemic has caused havoc all around the world. The causative agent of
COVID-19 is the novel form of the coronavirus (CoV) named SARS-CoV-2, which results in …

Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA

B Li, AY Jiang, I Raji, C Atyeo, TM Raimondo… - Nature Biomedical …, 2023 - nature.com
To elicit optimal immune responses, messenger RNA vaccines require intracellular delivery
of the mRNA and the careful use of adjuvants. Here we report a multiply adjuvanted mRNA …

Immunomodulatory approaches in managing lung inflammation in COVID‐19: a double‐edge sword

G Verma, M Dhawan, ARA Saied… - Immunity …, 2023 - Wiley Online Library
Introduction The novel coronavirus infectious disease 2019 (COVID‐19) which is caused by
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has emerged as a gigantic …

Variants of SARS-CoV-2: Influences on the vaccines' effectiveness and possible strategies to overcome their consequences

AA Rabaan, SH Al-Ahmed, H Albayat, S Alwarthan… - Medicina, 2023 - mdpi.com
The immune response elicited by the current COVID-19 vaccinations declines with time,
especially among the immunocompromised population. Furthermore, the emergence of …

Dynamic evolution of humoral and T-cell specific immune response to COVID-19 mRNA vaccine in patients with multiple sclerosis followed until the booster dose

S Ruggieri, A Aiello, C Tortorella, A Navarra… - International Journal of …, 2023 - mdpi.com
This study characterizes antibody and T-cell immune responses over time until the booster
dose of COronaVIrus Disease 2019 (COVID-19) vaccines in patients with multiple sclerosis …

Recombinant human interleukin-2 corrects NK cell phenotype and functional activity in patients with post-COVID syndrome

AA Savchenko, IV Kudryavtsev, DV Isakov… - Pharmaceuticals, 2023 - mdpi.com
Post-COVID syndrome develops in 10–20% of people who have recovered from COVID-19
and it is characterized by impaired function of the nervous, cardiovascular, and immune …

Design of the conserved epitope peptide of SARS-CoV-2 spike protein as the broad-spectrum COVID-19 vaccine

TY Chang, CJ Li, TL Chao, SY Chang… - Applied Microbiology and …, 2024 - Springer
Our previous study has found that monoclonal antibodies targeting a conserved epitope
peptide spanning from residues 1144 to 1156 of SARS-CoV-2 spike (S) protein, namely S …

COVID-19: from immune response to clinical intervention

Z Guo, Y Tang, Z Zhang, J Liu… - Precision Clinical …, 2024 - academic.oup.com
Abstract The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has highlighted the pivotal role of the immune …

[HTML][HTML] Gold Nanoparticle Virus-like Particles Presenting SARS-CoV-2 Spike Protein: Synthesis, Biophysical Properties and Immunogenicity in BALB/c Mice

VA Salazar, J Comenge, R Suárez-López, JA Burger… - Vaccines, 2024 - mdpi.com
Gold nanoparticles (AuNPs) decorated with antigens have recently emerged as promising
tools for vaccine development due to their innate ability to provide stability to antigens and …