Nrf2 as a target for prevention of age‐related and diabetic cataracts by against oxidative stress

XF Liu, JL Hao, T Xie, TH Malik, CB Lu, C Liu… - Aging cell, 2017 - Wiley Online Library
Cataract is one of the most important causes of blindness worldwide, with age‐related
cataract being the most common one. Agents preventing cataract formation are urgently …

The protective effects of flavonoids in cataract formation through the activation of Nrf2 and the inhibition of MMP-9

A Hilliard, P Mendonca, TD Russell, KFA Soliman - Nutrients, 2020 - mdpi.com
Cataracts account for over half of global blindness. Cataracts formations occur mainly due to
aging and to the direct insults of oxidative stress and inflammation to the eye lens. The …

Current trends in the pharmacotherapy of cataracts

SH Heruye, LN Maffofou Nkenyi, NU Singh… - Pharmaceuticals, 2020 - mdpi.com
Cataracts, one of the leading causes of preventable blindness worldwide, refers to lens
degradation that is characterized by clouding, with consequent blurry vision. As life …

Recent progress and research trend of anti-cataract pharmacology therapy: a bibliometric analysis and literature review

A Lu, P Duan, J Xie, H Gao, M Chen, Y Gong… - European Journal of …, 2022 - Elsevier
Cataract is the leading cause of blindness worldwide. Cataract phacoemulsification
combined with intraocular lens implantation causes great burden to global healthcare …

Antioxidant system and endoplasmic reticulum stress in cataracts

X Zhang, B Liu, K Lal, H Liu, M Tran, M Zhou… - Cellular and molecular …, 2023 - Springer
The primary underlying contributor for cataract, a leading cause of vision impairment and
blindness worldwide, is oxidative stress. Oxidative stress triggers protein damage, cell …

Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats

Y Maddirala, S Tobwala, H Karacal, N Ercal - BMC ophthalmology, 2017 - Springer
Background The present study sought to evaluate the efficacy of N-acetylcysteine amide
(NACA) eye drops in reversing the cataract formation induced by sodium selenite in male …

In vitro antioxidant and anticataractogenic potential of silver nanoparticles biosynthesized using an ethanolic extract of Tabernaemontana divaricata leaves

M Anbukkarasi, PA Thomas, JR Sheu… - Biomedicine & …, 2017 - Elsevier
Silver nanoparticles (AgNPs) have been found useful in biological systems and in medicine
since they possess a large surface area to volume ratio, which confers on them several …

Moringa oleifera Prevents Selenite-Induced Cataractogenesis in Rat Pups

V Sasikala, BN Rooban, SGS Priya… - Journal of ocular …, 2010 - liebertpub.com
Purpose: The aim of this study was to investigate the protective effects of the flavonoid
fraction of Moringa oleifera leaves (FMO) on selenite cataract in vivo. Methods: Rat pups of …

In vivo inhibition of l-buthionine-(S, R)-sulfoximine-induced cataracts by a novel antioxidant, N-acetylcysteine amide

JW Carey, EY Pinarci, S Penugonda, H Karacal… - Free Radical Biology …, 2011 - Elsevier
The effects of N-acetylcysteine amide (NACA), a free radical scavenger, on cataract
development were evaluated in Wistar rat pups. Cataract formation was induced in these …

Vitex negundo attenuates calpain activation and cataractogenesis in selenite models

BN Rooban, Y Lija, PG Biju, V Sasikala… - Experimental Eye …, 2009 - Elsevier
Recent investigations have shown that phytochemical antioxidants can scavenge free
radicals and prevent various diseases. Cataract is the leading cause of blindness and is …