Protein-based biological materials: Molecular design and artificial production

A Miserez, J Yu, P Mohammadi - Chemical Reviews, 2023 - ACS Publications
Polymeric materials produced from fossil fuels have been intimately linked to the
development of industrial activities in the 20th century and, consequently, to the …

Synthetic extracellular matrices with function-encoding peptides

C Ligorio, A Mata - Nature reviews bioengineering, 2023 - nature.com
The communication of cells with their surroundings is mostly encoded in the epitopes of
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …

Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology

D Osuna de la Peña, SMD Trabulo, E Collin… - Nature …, 2021 - nature.com
Patient-derived in vivo models of human cancer have become a reality, yet their turnaround
time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully …

[HTML][HTML] Biofabrication methods for reconstructing extracellular matrix mimetics

A Aazmi, D Zhang, C Mazzaglia, M Yu, Z Wang… - Bioactive Materials, 2024 - Elsevier
In the human body, almost all cells interact with extracellular matrices (ECMs), which have
tissue and organ-specific compositions and architectures. These ECMs not only function as …

Resilin-mimetics as a smart biomaterial platform for biomedical applications

R Balu, NK Dutta, AK Dutta, NR Choudhury - Nature Communications, 2021 - nature.com
Intrinsically disordered proteins have dramatically changed the structure–function paradigm
of proteins in the 21st century. Resilin is a native elastic insect protein, which features …

Recent advances in the fabrication, functionalization, and bioapplications of peptide hydrogels

Y Wang, W Zhang, C Gong, B Liu, Y Li, L Wang, Z Su… - Soft Matter, 2020 - pubs.rsc.org
Self-assembled peptide-based nanomaterials have exhibited wide application potential in
the fields of materials science, nanodevices, biomedicine, tissue engineering, biosensors …

In Situ Covalent Reinforcement of a Benzene‐1, 3, 5‐Tricarboxamide Supramolecular Polymer Enables Biomimetic, Tough, and Fibrous Hydrogels and Bioinks

S Hafeez, MC Decarli, A Aldana, M Ebrahimi… - Advanced …, 2023 - Wiley Online Library
Synthetic hydrogels often lack the load‐bearing capacity and mechanical properties of
native biopolymers found in tissue, such as cartilage. In natural tissues, toughness is often …

Rational design of hydrogels for immunomodulation

W Bu, Y Wu, AM Ghaemmaghami… - Regenerative …, 2022 - academic.oup.com
The immune system protects organisms against endogenous and exogenous harm and
plays a key role in tissue development, repair and regeneration. Traditional …

Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering

VP Gray, CD Amelung, IJ Duti, EG Laudermilch… - Acta biomaterialia, 2022 - Elsevier
A core challenge in biomaterials, with both fundamental significance and technological
relevance, concerns the rational design of bioactive microenvironments. Designed properly …

Designed protein-and peptide-based hydrogels for biomedical sciences

W Ahn, JH Lee, SR Kim, J Lee, EJ Lee - Journal of Materials Chemistry …, 2021 - pubs.rsc.org
Proteins are fundamentally the most important macromolecules for biochemical, mechanical,
and structural functions in living organisms. Therefore, they provide us with diverse structural …