Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …

Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …

Epithelial organoids, such as those derived from stem cells of the intestine, have great
potential for modelling tissue and disease biology,,–. However, the approaches that are …

In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …

A key challenge in analyzing single cell RNA-sequencing data is the large number of false
zeros, where genes actually expressed in a given cell are incorrectly measured as …

Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

Mesenchymal cells are mesoderm-derived stromal cells that are best known for providing
structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and …