Drug resistance, difficulty in specific targeting and self-renewal properties of cancer stem
cells (CSCs) all contribute to cancer treatment failure and relapse. CSCs have been …

Breast cancer remains a major cause of death in the United States as well as the rest of the
world. In view of the limited treatment options for patients with advanced breast cancer …

Abstract Celastrol (CEL), a plant-derived triterpenoid, is a known inhibitor of Hsp90 and NF-
κB activation pathways and has recently been suggested to be of therapeutic importance in …

Interest in the use of traditional medicines for cancer prevention and treatment is increasing.
In vitro, in vivo, and clinical studies suggest the potential use of proteasome inhibitors as …

Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook. f., have a long history
of use in traditional Chinese medicine. In recent years there has been considerable interest …

Alterations in protein folding and the regulation of conformational states have become
increasingly important to the functionality of key molecules in signaling, cell growth, and cell …

Cancer chemoprevention is defined as the use of natural or synthetic agents that reverse,
suppress or arrest carcinogenic and/or malignant phenotype progression towards invasive …

Celastrol, a quinone methide triterpene derived from the medicinal plant Tripterygium
wilfordii, has been used to treat chronic inflammatory and autoimmune diseases, but its …

Celastrol, a quinone methide triterpenoid, was isolated as an inhibitor of NF-κB from
Celastrus orbiculatus. This compound dose-dependently inhibited a variety of stimuli …

The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway
has been highly conserved throughout evolution, and isoprenoids are some of the most …