For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

Acute glaucoma is one of the leading causes of irreversible vision impairment characterized
by the rapid elevation of intraocular pressure (IOP) and consequent retinal ganglion cell …

There is a growing need for models of human diseases that utilise native, donated human
tissue in order to model disease processes and develop novel therapeutic strategies. In this …

Alterations to the mechanical properties of the microenvironment are a hallmark of cancer.
Elevated mechanical stresses exist in many solid tumors and elicit responses from cancer …

Hydrostatic pressure (HP) regulates diverse cell behaviors including differentiation,
migration, apoptosis, and proliferation. Abnormal HP is associated with pathologies …

Glaucoma, a leading cause of blindness worldwide, is a degenerative disease characterized
by retinal ganglion cell (RGC) loss and optic nerve atrophy. Elevated intraocular pressure …

AIM To assess the neuro-protective effect of bone marrow mesenchymal stem cells (BMSCs)
on retinal ganglion cells (RGCs) following optic nerve crush in mice. METHODS C56BL/6J …

Changes in hydrostatic pressure, at levels as low as 10 mm Hg, have been reported in some
studies to alter cell function in vitro; however, other studies have found no detectable …

Glaucoma is a heterogeneous eye disease causing atrophy of the optic nerve head (ONH).
The optic nerve is formed by the axons of the retinal ganglion cells (RGCs) that transmit …