Molecular regulations of circadian rhythm and implications for physiology and diseases
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
Circadian rhythm as a therapeutic target
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …
changes and internal physiology. The clock endows the host with temporal precision and …
Molecular mechanisms and physiological importance of circadian rhythms
A Patke, MW Young, S Axelrod - Nature reviews Molecular cell biology, 2020 - nature.com
To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
[HTML][HTML] Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair
Large bone defects resulting from fractures and disease are a major clinical challenge,
being often unable to heal spontaneously by the body's repair mechanisms. Lines of …
being often unable to heal spontaneously by the body's repair mechanisms. Lines of …
Interplay between circadian clock and cancer: new frontiers for cancer treatment
Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …
Crosstalk between metabolism and circadian clocks
H Reinke, G Asher - Nature Reviews Molecular Cell Biology, 2019 - nature.com
Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …
Advances in hypoxia-inducible factor biology
H Choudhry, AL Harris - Cell metabolism, 2018 - cell.com
Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …
Genomics of circadian rhythms in health and disease
F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …
processes. The central circadian clock exerts control over myriad aspects of mammalian …
The emerging link between cancer, metabolism, and circadian rhythms
S Masri, P Sassone-Corsi - Nature medicine, 2018 - nature.com
The circadian clock is a complex cellular mechanism that, through the control of diverse
metabolic and gene expression pathways, governs a large array of cyclic physiological …
metabolic and gene expression pathways, governs a large array of cyclic physiological …
Interconnections between circadian clocks and metabolism
Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …
environment; they are believed to be regulated by the core circadian clock interlocking …