Psychedelics make up a group of psychoactive compounds that induce hallucinogenic
effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated …

Agonists of seven-transmembrane receptors, also known as G protein-coupled receptors
(GPCRs), do not uniformly activate all cellular signalling pathways linked to a given seven …

A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …

Robustness is a ubiquitously observed property of biological systems. It is considered to be
a fundamental feature of complex evolvable systems. It is attained by several underlying …

It is useful to consider seven transmembrane receptors (7TMRs) as disordered proteins able
to allosterically respond to a number of binding partners. Considering 7TMRs as allosteric …

The concept of biased agonism has recently come to the fore with the realization that seven-
transmembrane receptors (7TMRs, also known as G protein–coupled receptors, or GPCRs) …

Members of the heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptor (GPCR) family play key roles in many physiological functions and are extensively …

Glycine is a major neurotransmitter involved in several fundamental neuronal processes.
The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine …

Constitutive receptor activity/inverse agonism and functional selectivity/biased agonism are
2 concepts in contemporary pharmacology that have major implications for the use of drugs …

G-protein-coupled receptors (GPCRs) constitute a large and diverse family of proteins
whose primary function is to transduce extracellular stimuli into intracellular signals. They …