Methylene blue (MB), the first synthetic drug, has a 120-year-long history of diverse
applications, both in medical treatments and as a staining reagent. In recent years there was …

Methylene Blue (MB), following its introduction to biology in the 19th century by Ehrlich, has
found uses in various areas of medicine and biology. At present, MB is the first line of …

Interest in the medial prefrontal cortex (mPFC) as a source of behavioral inhibition has
increased with the mounting evidence for a functional role of the mPFC in extinction of …

Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and
oxidative stress, which are important factors contributing to the development of brain …

The relationship between methylene blue (MB) and Alzheimer's disease (AD) has recently
attracted increasing scientific attention since it has been suggested that MB may slow down …

Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical
applications. Apart from its well-known applications in surgical staining, malaria, and …

Introduction Neurofibrillary tangles (NFT) composed of Tau are hallmarks of
neurodegeneration in Alzheimer disease. Transgenic mice expressing full-length pro …

This paper provides the first review of the memory-enhancing and neuroprotective metabolic
mechanisms of action of methylene blue in vivo. These mechanisms have important …

Methylene blue (MB), the first lead chemical structure of phenothiazine and other
derivatives, is commonly used in diagnostic procedures and as a treatment for …

Amyloid plaques are hallmark neuropathological lesions in Alzheimer's disease, which
consist of abnormally aggregated Aβ protein. Multiple Aβ aggregated species have been …