Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …

The dorsal striatum is a large forebrain region involved in action initiation, timing, control,
learning and memory. Learning and remembering skilled movement sequences requires the …

Allosteric modulation of GPCRs has initiated a new era of basic and translational discovery,
filled with therapeutic promise yet fraught with caveats. Allosteric ligands stabilize unique …

Glutamate receptors regulate gene expression in neurons by activating intracellular
signaling cascades that phosphorylate transcription factors within the nucleus. The mitogen …

Modulation of neurotransmitter release by G-protein-coupled receptors (GPCRs) is a
prominent presynaptic mechanism for regulation of synaptic transmission. Activation of …

Dyskinesias represent a major complication of dopamine replacement therapy in
Parkinson's disease (PD) and have prompted a search for alternative treatments. The most …

Long-term depression (LTD) of the efficacy of synaptic transmission is now recognized as an
important mechanism for the regulation of information storage and the control of actions, as …

Long-and short-term changes in the efficacy of synaptic transmission are known as synaptic
plasticity. Phenomena such as long-term depression (LTD) and long-term potentiation (LTP) …

Rationale To increase subtype selectivity and provide a novel means to alter receptor
function, we discovered and characterization potentiators for the metabotropic glutamate 2 …

Glutamatergic excitatory transmission is implicated in physiological and pathological
conditions like learning, memory, neuronal plasticity and emotions, while glutamatergic …