Sensorineural hearing impairment is the most common sensory disorder and a major health
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …

Carnitine is an essential metabolite that is absorbed from the diet and synthesized in the
kidney, liver, and brain. It ferries fatty acids across the mitochondrial membrane to undergo β …

Objective Cisplatin (CDDP) toxicity is a dose-limiting clinical problem in clinical practice,
mainly because of nephrotoxicity or ototoxicity. However, the mechanism of CDDP-induced …

The male factor is responsible for infertility in about 35–40% of all cases. Idiopathic oligo-
and/or astheno-and/or therato-zoospermia is one of the most common male fertility disorders …

Methods Sprague-Dawley rats that underwent UUO were treated daily with LC for 7 or 14
days. The influence of LC on renal injury caused by UUO was evaluated by histopathology …

Objectives Cisplatin is an anti‐neoplastic agent treatment with which causes many side
effects including ototoxicity. The aim of this study was to investigate whether acetyl‐l …

Aim Cisplatin chemotherapy is associated with neurotoxicity, and oxidative stress might play
an important role in the pathogenesis. Mirtazapine may be a preventative agent via its less …

Introduction Cisplatin (CIS), which is used as a therapeutic antineoplastic agent may
produce gonadotoxicity in a process linked to chemotherapy. Taurine, through its potential …

Ototoxicity is a well-known side effect of cisplatin. Some genetic and non-genetic risk factors
were described for cisplatin ototoxicity. Although there are some studies which point out a …

Background: Cisplatin, an effective antineoplastic agent, damages normal cells in a manner
related to chemotherapy. Acetyl L-carnitine protects cells against mitochondrial and nuclear …