Synchronization of biological clock neurons by light and peripheral feedback systems promotes circadian rhythms and health

A Ramkisoensing, JH Meijer - Frontiers in neurology, 2015 - frontiersin.org
In mammals, the suprachiasmatic nucleus (SCN) functions as a circadian clock that drives
24-h rhythms in both physiology and behavior. The SCN is a multicellular oscillator in which …

The circadian clock at the intercept of sleep and pain

V Palada, I Gilron, B Canlon, CI Svensson, E Kalso - Pain, 2020 - journals.lww.com
It is estimated that 50% to 88% of the patients with chronic pain suffer from inadequate
sleep. 94 Not only does pain disturb sleep, but insomnia symptoms often precede the onset …

Clocks in the wild: entrainment to natural light

C Schmal, H Herzel, J Myung - Frontiers in physiology, 2020 - frontiersin.org
Entrainment denotes a process of coordinating the internal circadian clock to external
rhythmic time-cues (Zeitgeber), mainly light. It is facilitated by stronger Zeitgeber signals and …

Circadian regulation of innate immunity in animals and humans and implications for human disease

J Poole, GB Kitchen - Seminars in Immunopathology, 2022 - Springer
Circadian rhythms are 24-h oscillating variations in physiology generated by the core
circadian clock. There is now a wide body of evidence showing circadian regulation of the …

The seasons within: a theoretical perspective on photoperiodic entrainment and encoding

C Schmal - Journal of Comparative Physiology A, 2024 - Springer
Circadian clocks are internal timing devices that have evolved as an adaption to the
omnipresent natural 24 h rhythmicity of daylight intensity. Properties of the circadian system …

Network structure of the master clock is important for its primary function

C Gu, J Li, J Zhou, H Yang, J Rohling - Frontiers in Physiology, 2021 - frontiersin.org
A master clock located in the suprachiasmatic nucleus (SCN) regulates the circadian rhythm
of physiological and behavioral activities in mammals. The SCN has two main functions in …

Recurring circadian disruption alters circadian clock sensitivity to resetting

TL Leise, A Goldberg, J Michael… - European Journal of …, 2020 - Wiley Online Library
A single phase advance of the light: dark (LD) cycle can temporarily disrupt synchrony of
neural circadian rhythms within the suprachiasmatic nucleus (SCN) and between the SCN …

Motif structure for the four subgroups within the suprachiasmatic nuclei affects its entrainment ability

W Zheng, C Gu, H Yang, JHT Rohling - Physical Review E, 2022 - APS
Circadian rhythms of physiological and behavioral activities are regulated by a central clock.
This clock is located in the bilaterally symmetrical suprachiasmatic nucleus (SCN) of …

[HTML][HTML] Heterogeneity of neuronal properties determines the collective behavior of the neurons in the suprachiasmatic nucleus

C Gu, P Wang, T Weng, H Yang… - Mathematical Biosciences …, 2019 - aimspress.com
Circadian rhythms have been observed in behavioral and physiological activities of living
things exposed to the natural 24 h light-darkness cycle. Interestingly, even under constant …

Impact of dispersed coupling strength on the free running periods of circadian rhythms

C Gu, JHT Rohling, X Liang, H Yang - Physical Review E, 2016 - APS
The dominant endogenous clock, named the suprachiasmatic nucleus (SCN), regulates
circadian rhythms of behavioral and physiological activity in mammals. One of the main …