Choosing the right cell line for renal cell cancer research

KK Brodaczewska, C Szczylik, M Fiedorowicz, C Porta… - Molecular cancer, 2016 - Springer
Cell lines are still a tool of choice for many fields of biomedical research, including oncology.
Although cancer is a very complex disease, many discoveries have been made using …

Erythropoietin and its derivatives: from tissue protection to immune regulation

B Peng, G Kong, C Yang, Y Ming - Cell death & disease, 2020 - nature.com
Erythropoietin (EPO) is an evolutionarily conserved hormone well documented for its
erythropoietic role via binding the homodimeric EPO receptor (EPOR) 2. In past decades …

Management of anaemia and iron deficiency in patients with cancer: ESMO Clinical Practice Guidelines

M Aapro, Y Beguin, C Bokemeyer, M Dicato… - Annals of …, 2018 - annalsofoncology.org
Anaemia and iron deficiency (ID) are frequent complications in patients with solid tumours or
haematological malignancies, particularly in patients treated with chemotherapeutic agents …

The role of PI3K/AKT and MAPK signaling pathways in erythropoietin signalization

Z Tóthová, M Šemeláková, Z Solárová, J Tomc… - International Journal of …, 2021 - mdpi.com
Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on various
types of cells and tissues. EPO and its receptor EPOR trigger signaling cascades …

Erythropoietin and cancer: the unintended consequences of anemia correction

N Debeljak, P Solár, AJ Sytkowski - Frontiers in immunology, 2014 - frontiersin.org
Until 1990, erythropoietin (EPO) was considered to have a single biological purpose and
action, the stimulation of red blood cell growth and differentiation. Slowly, scientific and …

[HTML][HTML] Choosing the right animal model for renal cancer research

P Sobczuk, A Brodziak, MI Khan, S Chhabra… - Translational …, 2020 - Elsevier
The increase in the life expectancy of patients with renal cell carcinoma (RCC) in the last
decade is due to changes that have occurred in the area of preclinical studies …

Targeting EPO and EPO receptor pathways in anemia and dysregulated erythropoiesis

N Rainville, E Jachimowicz… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Recombinant human erythropoietin (rhEPO) is a first-line therapeutic for the
anemia of chronic kidney disease, cancer chemotherapy, AIDS (Zidovudine therapy), and …

Ginsenoside Rg1 induces apoptosis through inhibition of the EpoR-mediated JAK2/STAT5 signalling pathway in the TF-1/Epo human leukemia cell line

J Li, Q Wei, GW Zuo, J Xia, ZM You, CL Li… - Asian Pacific Journal …, 2014 - koreascience.kr
Ginsenoside Rg1 is one effective anticancer and antioxidant constituent of total saponins of
Panax ginseng (TSPG), which has been shown to have various pharmacological effects. Our …

[HTML][HTML] Cytoprotective effects of erythropoietin: What about the lung?

L Haine, CH Yegen, D Marchant, JP Richalet… - Biomedicine & …, 2021 - Elsevier
Erythropoietin (Epo) is a pleiotropic cytokine, essential for erythropoiesis. Epo and its
receptor (Epo-R) are produced by several tissues and it is now admitted that Epo displays …

[HTML][HTML] Basic parameters of blood count, serum sodium, and creatinine as prognostic factors for renal cell carcinoma at five-year follow-up

M Życzkowski, G Prokopowicz… - … medical journal of …, 2018 - ncbi.nlm.nih.gov
Background Several nomograms were developed for predicting the potential recurrence and
cancer death risk in renal cell carcinoma patients. The combination of TNM classification …