Quid pro flow

A Laybourn, K Robertson, AG Slater - Journal of the American …, 2023 - ACS Publications
How do you get into flow? We trained in flow chemistry during postdoctoral research and are
now applying it in new areas: materials chemistry, crystallization, and supramolecular …

Accelerating reaction modeling using dynamic flow experiments, part 1: design space exploration

P Sagmeister, C Schiller, P Weiss, K Silber… - Reaction Chemistry & …, 2023 - pubs.rsc.org
As organic chemistry becomes an increasingly data-rich field, there is a need for methods to
rapidly build and parameterize models for further development. We demonstrate the …

Enhancing Optimization of Mixed Variables on a Robotic Flow Platform: Integrating Statistical Filtering with Nelder–Mead and Bayesian Methods

A Senthil Vel, KE Konan, D Cortés-Borda… - … Process Research & …, 2023 - ACS Publications
Synthetic chemistry has progressively integrated advanced optimization methods. While
traditional approaches often prioritize continuous variables, the significance of discrete …

[HTML][HTML] Continuous flow as an enabling technology for sustainable supramolecular chemistry

F Parveen, N Watson, AM Scholes, AG Slater - Current Opinion in Green …, 2024 - Elsevier
Supramolecular chemistry exploits non-covalent intramolecular interactions to form
structures such as host-guest complexes and crystalline porous materials. Supramolecular …

Ultra-fast and sustainable formal [3+ 3] cycloadditions enabled by mixed variable optimization on an automated micromole scale flow platform

KE Konan, AS Vel, A Abollé, D Cortés-Borda… - Reaction Chemistry & …, 2023 - pubs.rsc.org
Herein, we report a simple and comprehensive mixed variable optimization strategy which
enabled the development of ultra-fast formal [3+ 3]-cycloadditions of 1, 3-dicarbonyl …

Rapid investigation of the effect of binary and ternary solvent gradient mixtures on reaction outcomes using a continuous flow system

D Drelinkiewicz, TJA Corrie, RJ Whitby - Reaction Chemistry & …, 2024 - pubs.rsc.org
In a continuous flow process, generating a gradient of solvent composition with time and
monitoring of the reaction mixture as it leaves the reactor allows for rapid generation of …

Self-Optimizing Flow Reactions for Sustainability: An Experimental Bayesian Optimization Study

FL Wagner, P Sagmeister, TG Tampone… - ACS Sustainable …, 2024 - ACS Publications
Self-optimizing flow reactors have received significant attention in recent years, with
Bayesian optimization (BO) being identified as the most effective method for reaction …

[HTML][HTML] Dynamic Flow Experiments for Data-Rich Optimization

JD Williams, P Sagmeister, CO Kappe - Current Opinion in Green and …, 2024 - Elsevier
Flow chemistry is having an increasing influence on manufacturing in the chemical industry,
but significant barriers remain in the development of these continuous processes. Dynamic …

On a seamlessly replicable circular photoreactor for lab-scale continuous flow applications

YH Tsai, M Cattoen, G Masson, G Christen… - Reaction Chemistry & …, 2024 - pubs.rsc.org
A cost effective and replicable continuous flow circular photoreactor system is introduced. All
body parts of the reactor are 3D-printed, and the electronics are purchased from various …

[HTML][HTML] Process intensification of a catalytic-wall Taylor-Couette reactor through unconventional modulation of its angular speed

EA López-Guajardo, R Galluzzi… - Chemical Engineering …, 2024 - Elsevier
This study proposes a non-conventional operation of a Taylor-Couette reactor by introducing
a periodic flow perturbation as a modulated angular velocity of its inner cylinder. The …