Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

Abstract Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer
drug target. Many recent studies have provided convincing evidences of strong correlation …

The current predominant therapeutic paradigm is based on maximizing drug-receptor
occupancy to achieve clinical benefit. This strategy, however, generally requires excessive …

Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that
simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination …

Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …

Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3
ligase to a target protein to facilitate ubiquitination and subsequent degradation of that …

This article is part of a Minifocus on Ubiquitin. For further reading, please see related
articles: ʻUbiquitin and SUMO in DNA repair at a glanceʼ by Helle D. Ulrich (J. Cell Sci …

The fourth edition of the World Health Organization (WHO) classification of tumours of the
central nervous system, published in 2007, lists several new entities, including angiocentric …

Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the
regulation of gene expression by oxygen. In oxygenated and iron replete cells, HIF-α …