Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type
1 and type 2 diabetes. Despite~ 60 years of using STZ in animal diabetes research, some …

Predictive models are essential for advancing knowledge of brain disorders. High variation
in study outcomes hampers progress. To address the validity of predictive models, we …

Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global
health initiatives. Efforts to prevent the development of ADRD require understanding …

It is surprising that after more than a century using rodents for scientific research, there are
no clear, consensual, or consistent definitions for when a mouse or a rat becomes adult …

Nitric oxide (NO) is involved in many physiological and pathological processes in the human
body. At least two major pathways produce NO:(1) the L-arginine-NO-oxidative pathway in …

Abstract Virtual Control Groups (VCGs) based on Historical Control Data (HCD) in
preclinical toxicity testing have the potential to reduce animal usage. As a case study we …

Body mass results from a complex interplay between genetics and environment. Previous
studies of the genetic contribution to body mass have excluded repetitive regions due to the …

Highlights Protective efficacy of Quercetin-3-O-β-D-glucopyranoside-rich fraction (Q3G-RF)
from Spondias mombin role on Dichlorvos (DDVP) toxicity was studied. DDVP induced …

Background Exercise is an affordable and practical strategy to alleviate several detrimental
outcomes from the aging process, including sarcopenia. The elucidation of molecular …

Based on their proven anti-inflammatory and antioxidant effects, recent studies have
examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors …