Diabetes mellitus adversely affects the skeleton and is associated with an increased risk of
osteoporosis and fragility fractures. The mechanisms underlying low bone strength are not …

Peroxisome proliferator-activated receptor γ (PPARγ) is a critical factor for adipogenesis and
glucose metabolism, but accumulating evidence demonstrates the involvement of PPARγ in …

Background: Rosiglitazone and pioglitazone may increase the incidence of fractures. We
aimed to determine systematically the risk of fractures associated with thiazolidinedione …

OBJECTIVE—The purpose of this study was to examine possible factors associated with the
increased risk of fractures observed with rosiglitazone in A Diabetes Outcome Progression …

OBJECTIVE Thiazolidinediones and insulin are associated with a higher risk of fractures in
type 2 diabetic patients. Incretin hormones increase bone density in experimental models …

Aim Patients with type 2 diabetes mellitus (T2DM) have an increased risk of bone fractures.
A variable increase in fracture risk has been reported depending on skeletal site, diabetes …

Although patients with type 2 diabetes (T2DM) have an increased risk of hip fracture, risk of
vertebral fracture (VF) and its association with BMD are still unclear. We examined …

Lipodystrophy is a medical condition characterized by complete or partial loss of adipose
tissue. Not infrequently, lipodystrophy occurs in combination with pathological accumulation …

Background Thiazolidinediones may adversely affect the skeleton owing to decreased bone
formation and accelerated bone loss. Methods This study examines the association between …

Increased fracture risk, traditionally associated with type 1 diabetes, has lately been of great
concern in patients with type 2 diabetes. A variable increase in fracture risk has been …