The cell cycle is a complex process that involves numerous regulatory proteins that direct
the cell through a specific sequence of events culminating in mitosis and the production of …

Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation. So far, more than
ten CDKs have been described. Their direct interaction with cyclins allow progression …

The retinoblastoma gene (RB-1) was originally identified as the gene involved in hereditary
retinoblastoma. However, RB-1 mutations are found in a number of common mesenchymal …

We describe and discuss a method of protein extraction for Western blot analysis from
formalin-fixed, paraffin-embedded tissue sections. From 5-mm2 50-μm-thick tissue sections …

There is evidence to suggest that CDC25B phosphatase is an oncogenic protein. To
elucidate the role of CDC25B in colorectal carcinoma, we examined the expression of …

Id helix-loop-helix (HLH) proteins function as regulators of cell growth and differentiation and
when overexpressed can induce malignant transformation. In a series of 34 cases of primary …

Although activating mutations of fibroblast growth factor receptor 3 (FGFR3) are frequent in
bladder tumors, little information is available on their specific effects in urothelial cells or the …

Expression of cell cycle regulatory proteins was evaluated in premalignant and malignant
oral epithelial lesions, to test the hypothesis that protein regulation of the cell cycle may be …

Background: Cyclin-dependent kinase 2 (CDK2) has been studied due to its role in the cell-
cycle progression. The elucidation of the CDK2 structure paved the way to investigate the …

A family of conserved serine/threonine kinases known as cyclin-dependent kinases (CDKs)
drives orderly cell cycle progression in mammalian cells. Prior studies have suggested that …