Calcium and bone metabolism remain key concerns for space travelers, and ground-based
models of space flight have provided a vast literature to complement the smaller set of …

Introduction• Overview of signalling pathways involved in disuse‐induced muscle atrophy‐
Changes in protein synthesis and associated signalling pathways‐Several pathways …

The goal of this project was to examine the effects of artificial gravity (AG) on skeletal muscle
strength and key anabolic/catabolic markers known to regulate muscle mass. Two groups of …

As we approach the end of the first 50 years of human space travel, much has been learned
about adaptation to microgravity and the risks associated with extended‐duration space …

Short-radius centrifugation combined with exercise has been suggested as a potential
countermeasure against spaceflight deconditioning. Both the long-term and acute …

In the past 15 years, several group studies have identified the need to validate the role of
artificial gravity (AG) as countermeasure to physiological deconditioning during long …

The aims of this study were to 1) determine if hypergravity (HG) squats can produce foot
forces similar to those measured during 10-repetition maximum (10RM) squats using …

Microgravity during long-term space flights induces degeneration of articular cartilage.
Artificial gravity through centrifugation combined with exercise has been suggested as a …

Deconditioning of astronauts during long duration spaceflight, especially with regard to the
cardiovascular, musculo-skeletal, and neurological systems, is a well-recognized problem …

Astronauts experience important physiological adaptation to weightless environment,
including bone loss, muscle atrophy, cardiovascular deconditioning, and vestibular …