The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …

Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

Immune evasion is a pivotal event in tumor progression. To eliminate human cancer cells,
current immune checkpoint therapy is set to boost CD8+ T cell–mediated cytotoxicity …

Autophagy is best known for its role in organelle and protein turnover, cell quality control,
and metabolism. The autophagic machinery has, however, also adapted to enable protein …

Mixed lineage kinase domain‐like (MLKL) is the executioner in the caspase‐independent
form of programmed cell death called necroptosis. Receptor‐interacting serine/threonine …

Membrane contact sites (MCS) are intracellular regions where two organelles come closer
to exchange information and material. The majority of the endoplasmic reticulum (ER) MCS …

The bidirectional movement of lysosomes on microtubule tracks regulates their whole-cell
spatial arrangement. Arl8b, a small GTP-binding (G) protein, promotes lysosome …

Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins
that frequently targets substrates for proteasomal degradation. However it can also result in …

Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …

The endolysosomal system fulfils a myriad of cellular functions predicated on regulated
membrane identity progressions, collectively termed maturation. Mature or “late” endosomes …