[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
Nuclear long noncoding RNAs: key regulators of gene expression
A significant portion of the human genome encodes genes that transcribe long nonprotein-
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
Insights on the potential oncogenic impact of long non-coding RNA nicotinamide nucleotide transhydrogenase antisense RNA 1 in different cancer types; integrating …
NM El-Sheikh, AI Abulsoud, EF Wasfey… - Pathology-Research and …, 2022 - Elsevier
Long non-coding RNAs (lncRNAs) are becoming more prevalent in the cancer field arena,
with functional roles in both oncogenic and onco-suppressive pathways. Despite their …
with functional roles in both oncogenic and onco-suppressive pathways. Despite their …
Long noncoding RNA-enriched vesicles secreted by hypoxic cardiomyocytes drive cardiac fibrosis
F Kenneweg, C Bang, K Xiao, CM Boulanger… - … Therapy-Nucleic Acids, 2019 - cell.com
Long non-coding RNAs (lncRNAs) have potential as novel therapeutic targets in
cardiovascular diseases, but detailed information about the intercellular lncRNA shuttling …
cardiovascular diseases, but detailed information about the intercellular lncRNA shuttling …
Long noncoding RNA PURPL suppresses basal p53 levels and promotes tumorigenicity in colorectal cancer
Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation
results in elevated p53 levels to induce cell cycle arrest, apoptosis, and tumor suppression …
results in elevated p53 levels to induce cell cycle arrest, apoptosis, and tumor suppression …
SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage
Summary p53, master transcriptional regulator of the genotoxic stress response, controls cell-
cycle arrest and apoptosis following DNA damage. Here, we identify a p53-induced lncRNA …
cycle arrest and apoptosis following DNA damage. Here, we identify a p53-induced lncRNA …
A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells
Long noncoding RNAs (lncRNAs) are often associated with polysomes, indicating coding
potential. However, only a handful of endogenous proteins encoded by putative lncRNAs …
potential. However, only a handful of endogenous proteins encoded by putative lncRNAs …
Crosstalk between long non-coding RNAs and p53 signaling pathway in colorectal cancer: A review study
MM Khanifar, Z Zafari, M Sheykhhasan - Pathology-Research and Practice, 2023 - Elsevier
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and the third
leading cause of cancer-related fatalities. Long non-coding RNAs (lncRNAs) are key …
leading cause of cancer-related fatalities. Long non-coding RNAs (lncRNAs) are key …
Significance of lncRNA abundance to function
I Grammatikakis, A Lal - Mammalian Genome, 2022 - Springer
Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse cellular processes.
Although the vast majority of lncRNAs are expressed at lower levels compared to …
Although the vast majority of lncRNAs are expressed at lower levels compared to …
EGR1‐mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer
Z Ma, X Gao, Y Shuai, X Wu, Y Yan, X Xing… - Cell proliferation, 2021 - Wiley Online Library
Abstract Objectives Long non‐coding RNAs (lncRNAs) are key mediators in various
malignancies. Linc01503 was previously elucidated to promote gastric cancer (GC) cell …
malignancies. Linc01503 was previously elucidated to promote gastric cancer (GC) cell …