Leak currents, defined as voltage and time independent flows of ions across cell
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …

TRESK belongs to the K2P family of potassium channels, also known as background or leak
potassium channels due to their biophysical properties and their role regulating membrane …

The review summarizes the advances in medicinal chemistry of tetrazole biologically active
compounds and drugs over the past 15 years. Most of the considered compounds are at …

K2P potassium channels generate leak currents that stabilize the resting membrane
potential of excitable cells. Various K2P channels are implicated in pain, ischemia …

The search for new forms of already known drug compounds is an urgent problem of high
relevance as more potent drugs with fewer side effects are needed. The trifluoromethyl …

Fenamic acid-derived NSAIDs contain N-phenyl anthranilic acid as a pharmacophore with
pKa∼ 4, which is completely ionized at the physiological pH and is mainly excreted in the …

Background and Purpose Cloxyquin (5‐cloroquinolin‐8‐ol) has been described as an
activator of TRESK (K2P18. 1, TWIK‐related spinal cord K+ channel) background potassium …

Two-pore domain potassium (K2P) channels carry background (or leak) potassium current
and play a key role in regulating resting membrane potential and cellular excitability …

A method for the synthesis of flufenamic acid, a nonstereoidal anti-inflammatory drug
(NSAID) of the anthranilate family (fenams), is described as an experiment for the upper …

The possibilities of nuclear Overhauser effect spectroscopy (NOESY) for conformational
analysis of fenamate (eg, flufenamic acid) molecules were shown. It was established that the …