Whole genome sequencing contributions and challenges in disease reduction focused on malaria
Simple Summary Malaria is one of the most severe life-threatening human vector-borne
diseases worldwide today, leading to high mortality. Children under the age of five and …
diseases worldwide today, leading to high mortality. Children under the age of five and …
Lateral gene transfer mechanisms and pan-genomes in eukaryotes
Lateral gene transfer (LGT) is well known as an important driver of genome evolution in
bacteria and archaea, but its importance in eukaryote evolution has yet to be fully …
bacteria and archaea, but its importance in eukaryote evolution has yet to be fully …
A comparative evaluation of hybrid error correction methods for error-prone long reads
S Fu, A Wang, KF Au - Genome biology, 2019 - Springer
Background Third-generation sequencing technologies have advanced the progress of the
biological research by generating reads that are substantially longer than second …
biological research by generating reads that are substantially longer than second …
Comprehensive evaluation of non-hybrid genome assembly tools for third-generation PacBio long-read sequence data
V Jayakumar, Y Sakakibara - Briefings in bioinformatics, 2019 - academic.oup.com
Long reads obtained from third-generation sequencing platforms can help overcome the
long-standing challenge of the de novo assembly of sequences for the genomic analysis of …
long-standing challenge of the de novo assembly of sequences for the genomic analysis of …
Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq
Background Plasmodium parasites undergo several major developmental transitions during
their complex lifecycle, which are enabled by precisely ordered gene expression programs …
their complex lifecycle, which are enabled by precisely ordered gene expression programs …
[HTML][HTML] Progression of the canonical reference malaria parasite genome from 2002–2019
U Böhme, TD Otto, M Sanders, CI Newbold… - Wellcome open …, 2019 - ncbi.nlm.nih.gov
Here we describe the ways in which the sequence and annotation of the Plasmodium
falciparum reference genome has changed since its publication in 2002. As the malaria …
falciparum reference genome has changed since its publication in 2002. As the malaria …
Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal expanded transporter repertoire and duplication of …
Cryptosporidiosis is a leading cause of waterborne diarrheal disease globally and an
important contributor to mortality in infants and the immunosuppressed. Despite its …
important contributor to mortality in infants and the immunosuppressed. Despite its …
A survey of transcriptome complexity in Sus scrofa using single-molecule long-read sequencing
Y Li, C Fang, Y Fu, A Hu, C Li, C Zou, X Li… - DNA …, 2018 - academic.oup.com
Alternative splicing (AS) and fusion transcripts produce a vast expansion of transcriptomes
and proteomes diversity. However, the reliability of these events and the extend of …
and proteomes diversity. However, the reliability of these events and the extend of …
Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential
Abstract Background Plasmodium falciparum (Pf) whole-organism sporozoite vaccines have
been shown to provide significant protection against controlled human malaria infection …
been shown to provide significant protection against controlled human malaria infection …
Analysis of transcripts and splice isoforms in Medicago sativa L. by single-molecule long-read sequencing
Y Chao, J Yuan, T Guo, L Xu, Z Mu, L Han - Plant Molecular Biology, 2019 - Springer
Key message The full-length transcriptome of alfalfa was analyzed with PacBio single-
molecule long-read sequencing technology. The transcriptome data provided full-length …
molecule long-read sequencing technology. The transcriptome data provided full-length …