2019 Global NAFLD prevalence: a systematic review and meta-analysis

MH Le, YH Yeo, X Li, J Li, B Zou, Y Wu, Q Ye… - Clinical …, 2022 - Elsevier
Background & Aims The increasing rates of obesity and type 2 diabetes mellitus may lead to
increased prevalence of nonalcoholic fatty liver disease (NAFLD). We aimed to determine …

Global incidence of non-alcoholic fatty liver disease: A systematic review and meta-analysis of 63 studies and 1,201,807 persons

MH Le, DM Le, TC Baez, Y Wu, T Ito, EY Lee… - Journal of …, 2023 - Elsevier
Background & Aims The prevalence of non-alcoholic fatty liver disease (NAFLD) is
increasing. We aimed to estimate the pooled global NAFLD incidence. Methods We …

Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis

Q Ye, B Zou, YH Yeo, J Li, DQ Huang, Y Wu… - The lancet …, 2020 - thelancet.com
Background Although non-alcoholic fatty liver disease (NAFLD) is commonly associated
with obesity, it is increasingly being identified in non-obese individuals. We aimed to …

The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD)

DM Tanase, EM Gosav, CF Costea… - Journal of diabetes …, 2020 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one
of the most global problematic metabolic diseases with rapidly increasing prevalence and …

The crucial role and mechanism of insulin resistance in metabolic disease

X Zhao, X An, C Yang, W Sun, H Ji… - Frontiers in endocrinology, 2023 - frontiersin.org
Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

Comparative burden of metabolic dysfunction in lean NAFLD vs non-lean NAFLD-a systematic review and meta-analysis

A Tang, CH Ng, PH Phang, KE Chan, YH Chin… - Clinical …, 2023 - Elsevier
Background & Aims Nonalcoholic fatty liver disease (NAFLD) is traditionally associated with
obesity. However, there is a subtype of NAFLD, namely NAFLD in lean, that occurs without …

Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice

Z Yao, Y Gong, W Chen, S Shao, Y Song, H Guo… - Nature …, 2023 - nature.com
Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However,
during insulin resistance (IR), when insulin signalling is blunted and accompanied by …

A review of non‐alcoholic fatty liver disease in non‐obese and lean individuals

M Ahadi, K Molooghi, N Masoudifar… - Journal of …, 2021 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is one of the most common causes of hepatic
disorders. It represents a wide range of chronic liver diseases in patients with no history of …

[HTML][HTML] Non-alcoholic fatty liver disease: A review with clinical and pathological correlation

YY Chen, MM Yeh - Journal of the Formosan Medical Association, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in North
America and Europe, with increasing prevalence in other regions of the world. Its spectrum …

First-in-Asian double-blind randomized trial to assess the efficacy and safety of insulin sensitizer in nonalcoholic steatohepatitis patients

JF Huang, CY Dai, CF Huang, PC Tsai, ML Yeh… - Hepatology …, 2021 - Springer
Background The efficacy and safety of insulin sensitizer in Asians with non-alcoholic
steatohepatitis (NASH) remain elusive. Aims The double-blind, randomized, placebo …