The cultivation of cells in a favorable artificial environment has become a versatile tool in
cellular and molecular biology. Cultured primary cells and continuous cell lines are …

Over the past 30 years, a range of cystic fibrosis (CF) animal models have been generated
for research purposes. Different species, including mice, rats, ferrets, rabbits, pigs, sheep …

Introduction Cystic fibrosis (CF) is a life-threatening inherited disease caused by mutations
in the gene encoding the CF transmembrane conductance regulator (CFTR) protein, an …

Cytochrome P450 (CYP450) enzymes are membrane-bound blood proteins that are vital to
drug detoxification, cell metabolism, and homeostasis. CYP450s belonging to CYP families …

Antibody-drug conjugates (ADCs) enable the precise delivery of cytotoxic agents by
conjugating small-molecule drugs with monoclonal antibodies (mAbs). Over recent decades …

The lack of available treatments and fatal outcome in most lysosomal storage disorders
(LSDs) have spurred research on pathological mechanisms and novel therapies in recent …

Respiratory tract infections (RTI) are a major cause of morbidity and mortality in humans. A
large number of RTIs is caused by viruses, often resulting in more severe disease in infants …

Most laboratory models of head and neck squamous cell cancer (HNSCC) rely on
established immortalized cell lines, which carry inherent bias due to selection and clonality …

Complex heterogeneity is an important characteristic in the development of prostate cancer
(PCa), which further leads to the failure of known therapeutic options. PCa research has …

Prostate cancer mortality is ranked second among all cancer mortalities in men worldwide.
There is a great need for a method of efficient drug screening for precision therapy …