Evolution of the SARS‐CoV‐2 omicron variants BA. 1 to BA. 5: implications for immune escape and transmission

LB Shrestha, C Foster, W Rawlinson… - Reviews in Medical …, 2022 - Wiley Online Library
The first dominant SARS‐CoV‐2 Omicron variant BA. 1 harbours 35 mutations in its Spike
protein from the original SARS‐CoV‐2 variant that emerged late 2019. Soon after its …

[HTML][HTML] SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies

MG Cox, TP Peacock, WT Harvey, J Hughes… - Nature Reviews …, 2023 - nature.com
Monoclonal antibodies (mAbs) offer a treatment option for individuals with severe COVID-19
and are especially important in high-risk individuals where vaccination is not an option …

Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination

J Tang, C Zeng, TM Cox, C Li, YM Son, IS Cheon… - Science …, 2022 - science.org
SARS-CoV-2 mRNA vaccination induces robust humoral and cellular immunity in the
circulation; however, it is currently unknown whether it elicits effective immune responses in …

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

S Cele, L Jackson, DS Khoury, K Khan, T Moyo-Gwete… - Nature, 2022 - nature.com
The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B. 1.1. 529),
first identified in Botswana and South Africa, may compromise vaccine effectiveness and …

Real-world COVID-19 vaccine effectiveness against the Omicron BA. 2 variant in a SARS-CoV-2 infection-naive population

JJ Lau, SMS Cheng, K Leung, CK Lee, A Hachim… - Nature medicine, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron variant has demonstrated enhanced transmissibility and
escape of vaccine-derived immunity. Although first-generation vaccines remain effective …

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

L Liu, S Iketani, Y Guo, JFW Chan, M Wang, L Liu… - Nature, 2022 - nature.com
Abstract The B. 1.1. 529/Omicron variant of SARS-CoV-2 was only recently detected in
southern Africa, but its subsequent spread has been extensive, both regionally and globally …

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

WF Garcia-Beltran, KJS Denis, A Hoelzemer, EC Lam… - Cell, 2022 - cell.com
Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.
1/B. 1.1. 529) harboring up to 36 mutations in spike protein, the target of neutralizing …

Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost

F Muecksch, Z Wang, A Cho, C Gaebler, T Ben Tanfous… - Nature, 2022 - nature.com
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent
individuals,–. Despite the reduced protection from infection, individuals who received three …

Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA. 1 following homologous and heterologous CoronaVac or BNT162b2 vaccination

SMS Cheng, CKP Mok, YWY Leung, SS Ng… - Nature medicine, 2022 - nature.com
The Omicron variant is rapidly becoming the dominant SARS-CoV-2 virus circulating
globally. It is important to define reductions in virus neutralizing activity in the serum of …

Homologous and heterologous Covid-19 booster vaccinations

RL Atmar, KE Lyke, ME Deming… - … England Journal of …, 2022 - Mass Medical Soc
Background Although the three vaccines against coronavirus disease 2019 (Covid-19) that
have received emergency use authorization in the United States are highly effective …