There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …

Understanding functional effects of genetic variants is one of the key challenges in human
genetics, as much of disease-associated variation is located in non-coding regions with …

The human proteome is a major source of therapeutic targets. Recent genetic association
analyses of the plasma proteome enable systematic evaluation of the causal consequences …

The burden of human disease lies predominantly in polygenic diseases. Since the early
2000s, genome-wide association studies (GWAS) have identified genetic variants and loci …

Background Previous expression quantitative trait loci (eQTL) studies have identified
thousands of genetic variants to be associated with gene expression at the mRNA level in …

Obesity is a common complex trait that elevates the risk for various diseases, including type
2 diabetes and cardiovascular disease. A combination of environmental and genetic factors …

Because regulation of gene expression is heritable and context-dependent, we investigated
AD-related gene expression patterns in cell types in blood and brain. Cis-expression …

Background: Coronary artery disease (CAD) is the leading cause of death worldwide.
Recent meta-analyses of genome-wide association studies have identified over 175 loci …

Breeding bulls are well suited to investigate inherited variation in male fertility because they
are genotyped and their reproductive success is monitored through semen analyses and …

Wnt signaling is an ancient and evolutionarily conserved pathway with fundamental roles in
the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate …