Pelvic Inflammatory Disease Due to Neisseria gonorrhoeae and Chlamydia trachomatis: Immune Evasion Mechanisms and Pathogenic Disease Pathways

T Darville - The Journal of infectious diseases, 2021 - academic.oup.com
Pelvic inflammatory disease (PID) results from ascension of sexually transmitted pathogens
from the lower genital tract to the uterus and/or fallopian tubes in women, with potential …

A review of the challenges and complexities in the diagnosis, etiology, epidemiology, and pathogenesis of pelvic inflammatory disease

SL Hillier, KT Bernstein, S Aral - The Journal of infectious …, 2021 - academic.oup.com
Pelvic inflammatory disease (PID) is a syndrome that causes substantial morbidity, including
chronic pelvic pain, to women globally. While limited data are available from low-and middle …

Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?

LM de la Maza, TL Darville, S Pal - Expert review of vaccines, 2021 - Taylor & Francis
Introduction Chlamydia trachomatis is the most common sexually transmitted bacterial
pathogen in the world. Antibiotic treatment does not prevent against reinfection and a …

Advances in vaccine development for Chlamydia trachomatis

TB Poston - Pathogens and Disease, 2024 - academic.oup.com
Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection globally.
Antibiotic treatment is highly effective, but infection is often asymptomatic resulting in most …

Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection

TB Poston, DAE Lee, T Darville, W Zhong… - The Journal of …, 2019 - academic.oup.com
Background Chlamydia trachomatis can cause reproductive morbidities after ascending to
the upper genital tract of women, and repeated infection can lead to worse disease. Data …

Pathogenic Interplay Between Chlamydia trachomatis and Neisseria gonorrhoeae that Influences Management and Control Efforts—More Questions than Answers?

CA Leonard, RV Schoborg, N Low, M Unemo… - Current Clinical …, 2019 - Springer
Abstract Purpose of Review To emphasize key gaps in knowledge impacting efforts to
control single infection and co-infections with Chlamydia trachomatis (CT) and Neisseria …

Gene expression signatures can aid diagnosis of sexually transmitted infection-induced endometritis in women

X Zheng, CM O'Connell, W Zhong… - Frontiers in cellular …, 2018 - frontiersin.org
Sexually transmitted infection (STI) of the upper reproductive tract can result in inflammation
and infertility. A biomarker of STI-induced upper tract inflammation would be significant as …

Cervicovaginal microbial features predict Chlamydia trachomatis spread to the upper genital tract of infected women

S Jeong, T Tollison, H Brochu, H Chou, I Huntress… - bioRxiv, 2024 - biorxiv.org
Introduction Chlamydia trachomatis (CT) infection can lead to pelvic inflammatory disease,
infertility and other reproductive sequelae when it ascends to the upper genital tract. Factors …

Host Genetic Risk Factors for Chlamydia trachomatis-Related Infertility in Women

X Zheng, W Zhong, CM O'Connell, Y Liu… - The Journal of …, 2021 - academic.oup.com
Abstract Background Chlamydia trachomatis (Ct) infection ascending to the upper genital
tract can cause infertility. Direct association of genetic variants as contributors is challenging …

Genetic susceptibility loci for Chlamydia trachomatis endometrial infection influence expression of genes involved in T cell function, tryptophan metabolism and …

W Zhong, A Kollipara, Y Liu, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Objectives Identify genetic loci of enhanced susceptibility to Chlamydial trachomatis (Ct)
upper genital tract infection in women. Methods We performed an integrated analysis of …