Introduction 3. Development and determination of the myogenic lineage 3.1. Somitogenesis:
formation of epaxial versus hypaxial musculature 3.2. The myogenic regulatory factors 3.2 …

The adenovirus early region 1A (E1A) proteins were described originally as immortalizing
oncoproteins that altered transcription in rodent cells. Surprisingly, the 243-amino-acid form …

Cell proliferation and differentiation are highly coordinated processes during development.
Recent studies have revealed that this coordination may result from dual functions residing …

The molecular mechanism (s) that are responsible for suppressing MyoD's transcriptional
activities in undifferentiated skeletal muscle cells have not yet been determined. We now …

Small DNA tumor viruses have evolved different mechanisms to abrogate the function of the
retinoblastoma tumor suppressor (pRb). Studies of these viruses have been invaluable in …

Emery–Dreifuss muscular dystrophy (EDMD1) is caused by mutations in either the X-linked
gene emerin (EMD) or the autosomal lamin A/C (LMNA) gene. Here, we describe the …

The Rb/E2F complex represses S‐phase genes both in cycling cells and in cells that have
permanently exited from the cell cycle and entered a terminal differentiation pathway. Here …

RB, the most investigated tumor suppressor gene, is the founder of the RB family of
growth/tumor suppressors, which comprises also p107 (RBL1) and Rb2/p130 (RBL2). The …

Introduction 3. The E1A proteins 3.1. Early findings 3.2. Targeting the pRb checkpoint by
E1A 3.2. 1. pRb 3.2. 2. pRb family members 3.3. Targeting cyclin-Cdks by E1A 3.4. E1A …

The remarkable regenerative capacity displayed by plants and various vertebrates, such as
amphibians, is largely based on the capability of somatic cells to undergo dedifferentiation …