This review serves as a systematic guide to the genetics of generalized anxiety disorder
(GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry …

The addictions are common chronic psychiatric diseases that today are prevented and
treated using relatively untargeted and only partially effective methods. The addictions are …

Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the
prefrontal cortex of the human brain. Genetic variation in the COMT gene (MIM 116790) has …

• Genetic and environmental influences modulating risk of substance use disorders change
developmentally and across the lifespan.• Genes involved in vulnerability to addictions …

Diverse phenotypic associations with the catechol-O-methyltransferase (COMT) Val 158 Met
polymorphism have been reported. We suggest that some of the complex effects of this …

This article presents evidence suggesting that psychosocial stress may increase risk for
psychosis, especially in the case of cumulative exposure. A heuristically useful framework to …

This review summarizes our current understanding of catechol-o-methyltransferase (COMT)
and how it relates to brain function and schizophrenia. We begin by considering the COMT …

Women are more likely than men to suffer from post-traumatic stress disorder (PTSD) and
major depression. In addition to their sex bias, these disorders share stress as an etiological …

Genetic variation in catechol-O-methyltransferase (COMT), encoding an enzyme critical for
prefrontal dopamine flux, has been studied extensively using both behavioral and …

Objective: Rational therapeutic development in bipolar is hampered by a lack of
pathophysiological model. However, there is a wealth of converging data on the role of …