Apoptosis and the clearance of apoptotic cells are essential processes in animal
development and homeostasis. For apoptotic cells to be cleared, they must display an 'eat …

P4-ATPases comprise a family of P-type ATPases that actively transport or flip phospholipids
across cell membranes. This generates and maintains membrane lipid asymmetry, a …

The TMEM16 family of proteins, also known as anoctamins, features a remarkable functional
diversity. This family contains the long sought-after Ca2+-activated chloride channels as well …

Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are metabolically related
membrane aminophospholipids. In mammalian cells, PS is required for targeting and …

Phosphatidylserine (PS) is the major anionic phospholipid class particularly enriched in the
inner leaflet of the plasma membrane in neural tissues. PS is synthesized from …

It is well known that lipids are heterogeneously distributed throughout the cell. Most lipid
species are synthesized in the endoplasmic reticulum (ER) and then distributed to different …

In eukaryotic membranes, type IV P-type adenosine triphosphatases (P4-ATPases) mediate
the translocation of phospholipids from the outer to the inner leaflet and maintain lipid …

Abstract Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active
transport of phospholipids from exoplasmic or luminal leaflets to cytosolic leaflets of …

The movement of core-lipopolysaccharide across the inner membrane of Gram-negative
bacteria is catalysed by an essential ATP-binding cassette transporter, MsbA. Recent …

Membrane lipids diffuse rapidly in the plane of the membrane but their ability to flip
spontaneously across a membrane bilayer is hampered by a significant energy barrier. Thus …