[HTML][HTML] Metabolome analysis for investigating host-gut microbiota interactions

MX Chen, SY Wang, CH Kuo, IL Tsai - Journal of the Formosan Medical …, 2019 - Elsevier
Dysbiosis of the gut microbiome is associated with host health conditions. Many diseases
have shown to have correlations with imbalanced microbiota, including obesity …

Of drugs and trypanosomatids: new tools and knowledge to reduce bottlenecks in drug discovery

A Bhattacharya, A Corbeil, RL do Monte-Neto… - Genes, 2020 - mdpi.com
Leishmaniasis (Leishmania species), sleeping sickness (Trypanosoma brucei), and Chagas
disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by …

Localized cardiac small molecule trajectories and persistent chemical sequelae in experimental Chagas disease

Z Liu, R Ulrich vonBargen, AL Kendricks… - Nature …, 2023 - nature.com
Post-infectious conditions present major health burdens but remain poorly understood. In
Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that …

Persistent Biofluid Small-Molecule Alterations Induced by Trypanosoma cruzi Infection Are Not Restored by Parasite Elimination

DA Dean, J Roach, R Ulrich vonBargen… - ACS Infectious …, 2023 - ACS Publications
Chagas disease (CD), caused by Trypanosoma cruzi (T. cruzi) protozoa, is a complicated
parasitic illness with inadequate medical measures for diagnosing infection and monitoring …

Mapping of host-parasite-microbiome interactions reveals metabolic determinants of tropism and tolerance in Chagas disease

E Hossain, S Khanam, DA Dean, C Wu… - Science …, 2020 - science.org
Chagas disease (CD) is a parasitic disease caused by Trypanosoma cruzi protozoa,
presenting with cardiomyopathy, megaesophagus, and/or megacolon. To determine the …

Chagas disease is related to structural changes of the gut microbiota in adults with chronic infection (TRIPOBIOME Study)

JA Pérez-Molina, C Crespillo-Andújar… - PLoS neglected …, 2023 - journals.plos.org
Background The implications of the gut microbial communities in the immune response
against parasites and gut motility could explain the differences in clinical manifestations and …

Alterations in the gut microbiota of patients with silica-induced pulmonary fibrosis

Y Zhou, L Chen, G Sun, Y Li, R Huang - Journal of occupational medicine …, 2019 - Springer
Silicosis resulting from silica exposure is a global occupational disease characterized by
severe pathological changes in progressive pulmonary fibrosis. Previous evidence has …

Host‐parasite dynamics in Chagas disease from systemic to hyper‐local scales

D Pérez‐Mazliah, AI Ward, MD Lewis - Parasite immunology, 2021 - Wiley Online Library
Trypanosoma cruzi is a remarkably versatile parasite. It can parasitize almost any nucleated
cell type and naturally infects hundreds of mammal species across much of the Americas. In …

Central role of metabolism in Trypanosoma cruzi tropism and Chagas disease pathogenesis

Z Liu, R Ulrich vonBargen, LI McCall - Current opinion in microbiology, 2021 - Elsevier
Highlights•Trypanosoma cruzi parasites and Chagas disease show specific
tropism.•Metabolism is implicated in T. cruzi parasite tropism and Chagas disease …

Parasite infections, neuroinflammation, and potential contributions of gut microbiota

J Alloo, I Leleu, C Grangette, S Pied - Frontiers in Immunology, 2022 - frontiersin.org
Many parasitic diseases (including cerebral malaria, human African trypanosomiasis,
cerebral toxoplasmosis, neurocysticercosis and neuroschistosomiasis) feature acute or …