Marine natural products

AR Carroll, BR Copp, RA Davis, RA Keyzers… - Natural Product …, 2020 - pubs.rsc.org
This review covers the literature published between January and December in 2018 for
marine natural products (MNPs), with 717 citations (706 for the period January to December …

Peptide human neutrophil elastase inhibitors from natural sources: an overview

L Marinaccio, A Stefanucci, G Scioli… - International Journal of …, 2022 - mdpi.com
Elastases are a broad group of enzymes involved in the lysis of elastin, the main component
of elastic fibres. They are produced and released in the human body, mainly by neutrophils …

Native metabolomics identifies the rivulariapeptolide family of protease inhibitors

R Reher, AT Aron, P Fajtová, P Stincone… - Nature …, 2022 - nature.com
The identity and biological activity of most metabolites still remain unknown. A bottleneck in
the exploration of metabolite structures and pharmaceutical activities is the compound …

Marine cyanobacteria: A source of lead compounds and their clinically-relevant molecular targets

LT Tan, MY Phyo - Molecules, 2020 - mdpi.com
The prokaryotic filamentous marine cyanobacteria are photosynthetic microbes that are
found in diverse marine habitats, ranging from epiphytic to endolithic communities. Their …

Marine organisms as a prolific source of bioactive depsipeptides

M Zeng, J Tao, S Xu, X Bai, H Zhang - Marine Drugs, 2023 - mdpi.com
Depsipeptides, an important group of polypeptides containing residues of hydroxy acids and
amino acids linked together by amide and ester bonds, have potential applications in …

Progress in the discovery and development of anticancer agents from marine cyanobacteria

H Luesch, EK Ellis, QY Chen, R Ratnayake - Natural Product Reports, 2025 - pubs.rsc.org
Covering 2010–April 2024 There have been tremendous new discoveries and
developments since 2010 in anticancer research based on marine cyanobacteria. Marine …

[HTML][HTML] CTC-neutrophil interaction: A key driver and therapeutic target of cancer metastasis

C Hu, L Long, J Lou, M Leng, Q Yang, X Xu… - Biomedicine & …, 2024 - Elsevier
Circulating tumor cells (CTCs) are cancer cells that detach from the primary tumor and enter
the bloodstream, where they can seed new metastatic lesions in distant organs. CTCs are …

Structural Diversity and Biological Activity of Cyanopeptolins Produced by Nostoc edaphicum CCNP1411

R Konkel, M Cegłowska, K Szubert, E Wieczerzak… - Marine Drugs, 2023 - mdpi.com
Cyanopeptolins (CPs) are one of the most commonly occurring class of cyanobacterial
nonribosomal peptides. For the majority of these compounds, protease inhibition has been …

Harnessing Leptolyngbya for antiproliferative and antimicrobial metabolites through lens of modern techniques: A review

R Negi, M Nigam, RK Singh - Algal Research, 2024 - Elsevier
Cancer and antimicrobial resistance are pressing global health concerns, with cancer
ranking as a foremost reason of death across the world, estimated to be about 10 million in …

From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides

S Köcher, S Resch, T Kessenbrock, L Schrapp… - Natural Product …, 2020 - pubs.rsc.org
Covering: 1989 up to 2019 Ahp-cyclodepsipeptides (also known as Ahp-containing
cyclodepsipeptides, cyanopeptolins, micropeptins, microginines, and lyngbyastatins, and by …