Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

With the development of positron emission tomography (PET) technology, a variety of PET
imaging agents labeled with radionuclide 18 F have been developed and widely used in the …

Mitochondria-targeting positron emission tomography (PET) and fluorescent dual-modal
probes are rarely reported. As one of the most promising lipophilic cations, F16 and its …

Cancer is a growing problem that has not yet been fully harnessed. Frequent mutations
make this a highly variable and challenging pathology. Interestingly, mitochondria have …

In this study, we investigated the tumor targeting effect in cancer cells using
triphenylphosphonium (TPP) cations, which are accumulated by differences in membrane …

Radiolabelled lipophilic cations that accumulate in mitochondria according to the magnitude
of the mitochondrial membrane potential can be used to report non-invasively on …

Radiolabelled lipophilic cations can be used to non-invasively report on mitochondrial
dysfunction in diseases such as cardiovascular disease, cardiotoxicity and cancer. Several …

Coronary artery disease (CAD) is the leading cause of death in the world. Myocardial
perfusion imaging (MPI) plays a significant role in non-invasive diagnosis and prognosis of …

A novel strategy for the synthesis of sulfides and selenides from phosphonium salts and thio-
or selenesulfonates, commercially available compounds, is described. When phosphoranes …

The use of a triphenylarsonium vector for tumour cell-targeting leads to a dramatic increase
in Gd3+ uptake in human glioblastoma multiforme cells by up to an order of magnitude over …