Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …

Background There is an extensive literature highlighting the utility of blood-based liquid
biopsies in several extracranial tumors for diagnosis and monitoring. Methods The RANO …

BACKGROUND Patients with diffuse midline gliomas (DMGs), including diffuse intrinsic
pontine glioma (DIPG), have dismal outcomes. We previously described the H3. 3K27M …

Purpose: PNOC003 is a multicenter precision medicine trial for children and young adults
with newly diagnosed diffuse intrinsic pontine glioma (DIPG). Patients and Methods: Patients …

Response criteria for paediatric high-grade glioma vary historically and across different
cooperative groups. The Response Assessment in Neuro-Oncology working group …

Simple Summary Childhood cancers are mostly of unknown etiology and represent
devastating diagnoses. The clinical benefits of steadily increasing tumor control and survival …

Background The ability to identify genetic alterations in cancers is essential for precision
medicine; however, surgical approaches to obtain brain tumor tissue are invasive. Profiling …

Pediatric high-grade glioma (pHGG) is a major contributor to cancer-related death in
children. In vitro and in vivo disease models reflecting the intimate connection between …

Background The dismal prognosis of glioblastoma (GBM) may be related to the ability of
GBM cells to develop mechanisms of treatment resistance. We designed a protocol called …

Simple Summary H3K27M-mutant diffuse midline glioma is a rare childhood cancer
originating in midline brain structures. The H3K27M mutation substitutes an amino acid on …