Ciliogenesis is a complex multistep process used to describe assembly of cilia and flagella.
These organelles play essential roles in motility and signaling on the surface of cells. Cilia …

Cilia sense and transduce sensory stimuli, homeostatic cues and developmental signals by
orchestrating signaling reactions. Extracellular vesicles (EVs) that bud from the ciliary …

Oral-facial-digital syndromes (OFDS) are a group of clinically and genetically
heterogeneous disorders characterized by defects in the development of the face and oral …

Ciliogenesis describes the assembly of cilia in interphase cells. Several hundred proteins
have been linked to ciliogenesis, which proceeds through a highly coordinated multistage …

Vital internal organs display a left-right (LR) asymmetric arrangement that is established
during embryonic development. Disruption of this LR asymmetry—or laterality—can result in …

The primary cilium is a microtubule-based cellular protrusion found on most mammalian cell
types in diverse tissues. It functions as a cellular antenna to sense and transduce a broad …

Cilia protrude from the cell surface and play critical roles in intracellular signaling,
environmental sensing, and development. Reduced actin-dependent contractility and …

Tunneling nanotubes (TNTs) are F-actin rich structures that connect distant cells, allowing
the transport of many cellular components, including vesicles, organelles and molecules …

RAB35 is a multifunctional small GTPase that regulates endocytic recycling, cytoskeletal
rearrangement, and cytokinesis. However, its physiological functions in mammalian …

Primary cilia are sensory antennae crucial for cell and organism development, and defects
in their biogenesis cause ciliopathies. Ciliogenesis involves membrane trafficking mediated …