Staphylococcus aureus is a member of the human commensal microflora that exists,
apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it …

It has been 10 years since the introduction of modern transposon-insertion sequencing (TIS)
methods, which combine genome-wide transposon mutagenesis with high-throughput …

Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results
in a range of clinical presentations in humans. Most infections manifest as a clinically …

Vaccine-induced high-avidity IgA can protect against bacterial enteropathogens by directly
neutralizing virulence factors or by poorly defined mechanisms that physically impede …

The emergence of antibiotic-resistant bacteria through mutations or the acquisition of
genetic material such as resistance plasmids represents a major public health issue …

Antivirulence drugs are a new type of therapeutic drug that target virulence factors,
potentially revitalising the drug-development pipeline with new targets. As antivirulence …

Staphylococcus aureus is a human commensal that can also cause systemic infections. This
transition requires evasion of the immune response and the ability to exploit different niches …

Antibiotic therapy often fails to eliminate a fraction of transiently refractory bacteria, causing
relapses and chronic infections. Multiple mechanisms can induce such persisters with high …

Transposon insertion sequencing (TIS) is a powerful approach that can be extensively
applied to the genome-wide definition of loci that are required for bacterial growth under …

Inflammasomes can prevent systemic dissemination of enteropathogenic bacteria. As
adapted pathogens including Salmonella Typhimurium (S. Tm) have evolved evasion …