Primary blast brain injury mechanisms: current knowledge, limitations, and future directions

E Fievisohn, Z Bailey, A Guettler… - Journal of …, 2018 - asmedigitalcollection.asme.org
Mild blast traumatic brain injury (bTBI) accounts for the majority of brain injury in United
States service members and other military personnel worldwide. The mechanisms of primary …

Role of glia in memory deficits following traumatic brain injury: biomarkers of glia dysfunction

VSSS Sajja, N Hlavac, PJ VandeVord - Frontiers in integrative …, 2016 - frontiersin.org
Historically, glial cells have been recognized as a structural component of the brain.
However, it has become clear that glial cells are intimately involved in the complexities of …

Traumatic white matter injury and glial activation: from basic science to clinics

Z Kou, PJ VandeVord - Glia, 2014 - Wiley Online Library
An improved understanding and characterization of glial activation and its relationship with
white matter injury will likely serve as a novel treatment target to curb post injury …

A reanalysis of experimental brain strain data: implication for finite element head model validation

Z Zhou, X Li, S Kleiven, CS Shah… - SAE 62nd Stapp Car …, 2019 - diva-portal.org
Relative motion between the brain and skull and brain deformation are biomechanics
aspects associated with many types of traumatic brain injury (TBI). Thus far, there is only one …

The imbalance of astrocytic mitochondrial dynamics following blast-induced traumatic brain injury

F Guilhaume-Correa, AM Pickrell, PJ VandeVord - Biomedicines, 2023 - mdpi.com
Mild blast-induced traumatic brain injury (bTBI) is a modality of injury that has been of major
concern considering a large number of military personnel exposed to explosive blast waves …

Development of an unbiased validation protocol to assess the biofidelity of finite element head models used in prediction of traumatic brain injury

C Giordano, S Kleiven - 2016 - sae.org
This study describes a method to identify laboratory test procedures and impact response
requirements suitable for assessing the biofidelity of finite element head models used in …

[HTML][HTML] Neuronal release of cytokine IL-3 triggered by mechanosensitive autostimulation of the P2X7 receptor is neuroprotective

JC Lim, W Lu, JM Beckel, CH Mitchell - Frontiers in cellular …, 2016 - frontiersin.org
Mechanical strain due to increased pressure or swelling activates inflammatory responses in
many neural systems. As cytokines and chemokine messengers lead to both pro …

Studies on blast traumatic brain injury using in-vitro model with shock tube

P Arun, J Spadaro, J John, RB Gharavi, TB Bentley… - …, 2011 - journals.lww.com
One of the major limitations in studying the mechanisms of blast-induced traumatic brain
injury (bTBI) or screening therapeutics for protection is the lack of suitable laboratory model …

Traumatic injury activates MAP kinases in astrocytes: mechanisms of hypothermia and hyperthermia

T Huang, J Solano, D He, M Loutfi… - Journal of …, 2009 - liebertpub.com
Hyperthermia is common following traumatic brain injury (TBI) and has been associated with
poor neurologic outcome, and hypothermia has emerged as a potentially effective therapy …

Blast overpressure waves induce transient anxiety and regional changes in cerebral glucose metabolism and delayed hyperarousal in rats

HO Awwad, LP Gonzalez, P Tompkins, M Lerner… - Frontiers in …, 2015 - frontiersin.org
Physiological alterations, anxiety, and cognitive disorders are strongly associated with blast-
induced traumatic brain injury (blast TBI), and are common symptoms in service personnel …