Past, Present, and Future of RNA Modifications in Infectious Disease Research
X Pan, A Bruch, MG Blango - ACS Infectious Diseases, 2024 - ACS Publications
In early 2024, the National Academies of Sciences, Engineering, and Medicine (NASEM)
released a roadmap for the future of research into mapping ribonucleic acid (RNA) …
released a roadmap for the future of research into mapping ribonucleic acid (RNA) …
tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in Aspergillus fumigatus<?mode longmeta?>
A Bruch, V Lazarova, M Berg, T Krüger… - Nucleic Acids …, 2024 - academic.oup.com
Increasing antifungal drug resistance is a major concern associated with human fungal
pathogens like Aspergillus fumigatus. Genetic mutation and epimutation mechanisms clearly …
pathogens like Aspergillus fumigatus. Genetic mutation and epimutation mechanisms clearly …
Molecular basis for thiocarboxylation and release of Urm1 by its E1-activating enzyme Uba4
M Sokołowski, D Kwasna… - Nucleic Acids …, 2024 - academic.oup.com
Abstract Ubiquitin-related modifier 1 (Urm1) is a highly conserved member of the ubiquitin-
like (UBL) family of proteins. Urm1 is a key component of the eukaryotic transfer RNA (tRNA) …
like (UBL) family of proteins. Urm1 is a key component of the eukaryotic transfer RNA (tRNA) …
tRNA thiolation optimizes appressorium-mediated infection by enhancing codon-specific translation in Magnaporthe oryzae
X Zhang, R He, Y Li, S Ren, S Xiang… - Nucleic Acids …, 2025 - academic.oup.com
Thiolation, a post-transcriptional modification catalyzed by Uba4-Urm1-Ncs2/Ncs6 pathway
in three specific transfer RNAs (tRNAs), is conserved from yeast to humans and plays an …
in three specific transfer RNAs (tRNAs), is conserved from yeast to humans and plays an …
A highly conserved tRNA modification contributes to C. albicans filamentation and virulence
B Böttcher, SD Kienast, J Leufken, C Eggers… - Microbiology …, 2024 - Am Soc Microbiol
ABSTRACT tRNA modifications play important roles in maintaining translation accuracy in
all domains of life. Disruptions in the tRNA modification machinery, especially of the …
all domains of life. Disruptions in the tRNA modification machinery, especially of the …
tRNA modifications tune decoding of codon pairs to prevent cellular quality control responses
J Wu, C Eggers, O Sin, Ł Koziej, H Mancilla, F Mollet… - bioRxiv, 2024 - biorxiv.org
Abstract tRNA modifications tune translation rates and codon optimality, thereby optimizing
co-translational protein folding, but how codon optimality defects trigger cellular phenotypes …
co-translational protein folding, but how codon optimality defects trigger cellular phenotypes …
RNA as a Mediator of Host-Fungal Pathogenesis
A Bruch, MG Blango - Human and Animal Relationships, 2024 - Springer
In this chapter, we explore the wide range of functions RNA plays in mediating interactions
between fungi and their hosts in the animal kingdom. We cover examples of RNA in the …
between fungi and their hosts in the animal kingdom. We cover examples of RNA in the …
tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in Aspergillus fumigatus
A Bruch, V Lazarova, M Berg, T Krüger, S Schäuble… - bioRxiv, 2024 - biorxiv.org
Increasing antifungal drug resistance is a major concern associated with human fungal
infections. Genetic mutation and epimutation mechanisms are clear drivers of resistance, yet …
infections. Genetic mutation and epimutation mechanisms are clear drivers of resistance, yet …
Codon Pair-Specific Translation Defects Trigger Ribosome-Associated Quality Control to Avoid Proteotoxic Stress
J Wu, C Eggers, O Sin, Ł Koziej, H Mancilla, F Mollet… - 2024 - europepmc.org
tRNA modifications tune translation rates and codon optimality, thereby optimizing co-
translational protein folding, but how codon optimality defects trigger cellular phenotypes …
translational protein folding, but how codon optimality defects trigger cellular phenotypes …
[引用][C] Genome-wide Analysis papers
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