Havoc in harmony: Unravelling the intricacies of angiogenesis orchestrated by the tumor microenvironment

SS Acharya, CN Kundu - Cancer Treatment Reviews, 2024 - Elsevier
Cancer cells merely exist in isolation; rather, they exist in an intricate microenvironment
composed of blood vessels, signalling molecules, immune cells, stroma, fibroblasts, and the …

Near infrared-responsive quinacrine–gold hybrid nanoparticles deregulate HSP-70/P300-mediated H3K14 acetylation in ER/PR+ breast cancer stem cells

SR Dash, C Das, B Das, AB Jena, S Paul, S Sinha… - …, 2024 - Taylor & Francis
Aim: This study aimed to determine if quinacrine–gold hybrid nanoparticles (QAuNPs)+ near-
infrared (NIR) deregulate HSP-70/P300 complex-mediated H3K14 acetylation in estrogen …

Scaffold overlay of flavonoid-inspired molecules: Discovery of 2, 3-diaryl-pyridopyrimidin-4-imine/ones as dual hTopo-II and tubulin targeting anticancer agents

M Saini, S Paul, A Acharya, SS Acharya, CN Kundu… - Bioorganic …, 2024 - Elsevier
Almost half of all medicines approved by the US Food and Drug Administration have been
found to be developed based on inspiration from natural products (NPs). Here, we report a …

Resveratrol nanoparticles induce apoptosis in oral cancer stem cells by disrupting the interaction between β-catenin and GLI-1 through p53-independent activation of …

S Bhal, B Das, S Sinha, C Das, SS Acharya, J Maji… - Medical Oncology, 2024 - Springer
Cancer stem cells (CSCs) are mainly responsible for tumorigenesis, chemoresistance, and
cancer recurrence. CSCs growth and progression are regulated by multiple signaling …

Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents

VK Rao, S Paul, M Gulkis, Z Shen, H Nair… - RSC Medicinal …, 2024 - pubs.rsc.org
DNA polymerase β (Polβ) is crucial for the base excision repair (BER) pathway of DNA
damage repair and is an attractive target for suppressing tumorigenesis as well as …