Members of the APOBEC family of cellular cytidine deaminases represent a recently
identified group of proteins that provide immunity to infection by retroviruses and protect the …

The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …

Retroviruses have an intricate life cycle. There is much to be learned from studying retrovirus-
host interactions. Among retroviruses, the primate lentiviruses have one of the more complex …

ABSTRACT APOBEC3G (APO3G) is a cellular cytidine deaminase with potent antiviral
activity. Initial studies of the function of APO3G demonstrated extensive mutation of the viral …

Alternative splicing plays a key role in the HIV-1 life cycle and is essential to maintain an
equilibrium of mRNAs that encode viral proteins and polyprotein-isoforms. In particular …

Viral infectivity factor, an accessory protein encoded in the HIV-1 genome, induces G2 cell
cycle arrest; however, the biological significance and mechanism (s) remain totally unclear …

Efficient HIV-1 replication depends on balanced levels of host cell components including
cellular splicing factors as the family of serine/arginine-rich splicing factors (SRSF, 1–10) …

The ubiquitin–proteasome system plays an important role in the cell under normal
physiological conditions but also during viral infections. Indeed, many auxiliary proteins from …

Background The human immunodeficiency virus Vif protein overcomes the inhibitory activity
of the APOBEC3G cytidine deaminase by prohibiting its packaging into virions. Inhibition of …

While the Vif protein of human immunodeficiency virus type 1 (HIV-1) is essential for viral
replication in non-permissive cells, it is rapidly degraded intracellularly. We have previously …