During the last four decades, proliferative vitreoretinopathy (PVR) has defied the efforts of
many researchers to prevent its occurrence or development. Thus, PVR is still the major …

Rhegmatogenous retinal detachment (RRD) is a sight threatening condition that warrants
immediate surgical intervention. To date, 29 genes have been associated with monogenic …

Purpose To review the role of inflammatory mediators in proliferative vitreoretinopathy (PVR)
development and the current treatment for PVR prevention. Methods A PubMed search was …

Floaters and flashes are most commonly symptoms of age-related degenerative changes in
the vitreous body and posterior vitreous detachment. The etiology and pathogenesis of …

Abstract Interleukin-6 (IL-6) is one of the key regulators behind the inflammatory and
pathological process associated with ophthalmic diseases. The role of IL-6-174 G/C …

Epithelial to mesenchymal transition (EMT) is a biological process involved in tissue
morphogenesis and disease that causes dramatic changes in cell morphology, migration …

Abstract Mouse double minute 2 (MDM2), an E3 ubiquitin ligase and the primary negative
regulator of the tumor suppressor p53, cooperates with its structural homolog MDM4/MDMX …

Background Aqueous flare as determined by laser flare photometry in the anterior chamber
is a strong preoperative predictor for proliferative vitreoretinopathy (PVR) in patients with …

Proliferative vitreoretinopathy (PVR) is a metaplasia in the vitreous of the eye manifested by
the transformation of retinal pigment epithelial (RPE) cells and the development of …

OBJECTIVE: To assess the genetic contribution to proliferative vitreoretinopathy (PVR) and
report the strong association observed in the tumor necrosis factor (TNF) locus. DESIGN: As …