Despite persistent and substantial efforts, latent HIV-1 remains a formidable challenge to a
functional cure. Determined and continued commitment is needed to understand the …

Cells that are latently infected with HIV-1 preclude an HIV-1 cure, as antiretroviral therapy
does not target this latent population. HIV-1 is highly genetically diverse, with over 10 …

ABSTRACT NF-κB-interacting long noncoding RNA (NKILA) was recently identified as a
negative regulator of NF-κB signaling and plays an important role in the development of …

Stochastic fluctuations in gene expression emanating from the HIV-1 long terminal repeat
(LTR), amplified by the Tat positive feedback circuit, determine the choice between viral …

Many seminal advances have been made in human immunodeficiency virus (HIV)/AIDS
research over the past four decades. Treatment strategies, such as gene therapy and …

Functional mapping of the 5'LTR has shown that the U3 and the R regions (U3R) contain a
cluster of regulatory elements involved in the control of HIV-1 transcription and expression …

A genetic bottleneck is a hallmark of HIV-1 transmission such that only very few viral strains,
termed transmitted/founder (T/F) variants establish infection in a newly infected host …

The magnitude of transcription factor binding site variation emerging in HIV-1 subtype C
(HIV-1C), especially the addition of NF-κB motifs by sequence duplication, makes the …

Recent spread of the promoter variant (4-κB) Human immunodeficiency virus-1 clade C (HIV-
1C) strain is attributed to duplication of the Nuclear Factor Kappa B (NF-κB) binding sites …

Introduction HIV‐1‐infected patients develop haematological disorders such as cytopenias.
One possible explanation is the inhibition of haematopoiesis at the level of differentiation of …