When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-
sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are …

Aging-related cellular and molecular processes including low-grade inflammation are major
players in the pathogenesis of cardiovascular disease (CVD) and Alzheimer's disease (AD) …

When blood is exposed to negatively charged surface materials such as glass, an enzymatic
cascade known as the contact system becomes activated. This cascade is initiated by …

There exists a family of currently untreatable, serious human diseases that arise from the
inappropriate misfolding and aggregation of extracellular proteins. At present our …

Proteins are essential elements for life. They are building blocks of all organisms and the
operators of cellular functions. Humans produce a repertoire of at least 30,000 different …

It is now apparent that platelet function is more diverse than originally thought, shifting the
view of platelets from blood cells involved in hemostasis and wound healing to major …

Age-related, diet-related and protein conformational diseases, such as atherosclerosis,
diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative …

Alongside their function in primary haemostasis and thrombo-inflammation, platelets are
increasingly considered a bridge between mental, immunological and coagulation-related …

The use of the carbohydrate glucose as an energetic source is essential for an adequate
function of the human body. The complex regulation of this molecule involves the …

Alzheimer's disease (AD) is the most common neurodegenerative cause of dementia in the
elderly. AD is accompanied by the accumulation of amyloid peptides in the brain …